7 Result(s)

Article

Inhibition of NRF2 enhances the acute myeloid leukemia cell death induced by venetoclax via the ferroptosis pathway

Venetoclax, an inhibitor that selectively targets B cell lymphoma-2 (BCL-2) that has been approved for treating adult acute myeloid leukemia (AML) in combination with hypomethylating agents. However, its short...

**bao Yu, Yan Wang, Jiaxiong Tan, Yuchen Li, Pengyue Yang, Xuan Liu… in Cell Death Discovery (2024)

Article

Correction: Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy

Letong Cai, Yuchen Li, Jiaxiong Tan, Ling Xu… in Journal of Hematology & Oncology (2023)

Article

Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy

In one decade, immunotherapy based on immune checkpoint blockades (ICBs) has become a new pillar of cancer treatment following surgery, radiation, chemotherapy, and targeted therapies. However, not all cancer ...

Letong Cai, Yuchen Li, Jiaxiong Tan, Ling Xu… in Journal of Hematology & Oncology (2023)

Article

Targeting TIM-3 for hematological malignancy: latest updates from the 2022 ASH annual meeting

T cell immunoglobulin domain and mucin domain-3 (TIM-3) is an important immune checkpoint (IC) protein in cancer immunosuppression that is considered a novel target for immunotherapy. Moreover, TIM-3, an immun...

Jiaxiong Tan, Huo Tan, Yangqiu Li in Experimental Hematology & Oncology (2023)

Article

Increased TOX expression associates with exhausted T cells in patients with multiple myeloma

Previous studies have shown increased aberrant expression of immune checkpoint (IC) proteins, such as programmed cell death receptor-1 (PD-1) and T cell immunoglobulin mucin-domain-containing-3 (Tim-3) on T ce...

Yujie Zhao, Pengjun Liao, Shuxin Huang, Tairan Deng… in Experimental Hematology & Oncology (2022)

Article

Increased PD-1+Tim-3+ exhausted T cells in bone marrow may influence the clinical outcome of patients with AML

Altered expression of T cell immune inhibitory receptors may result in immunosuppression and associate with the poor prognosis of leukemia patients in which the leukemic bone marrow (BM) microenvironment may c...

Jiaxiong Tan, Zhi Yu, **gying Huang, Youchun Chen, Shuxin Huang… in Biomarker Research (2020)

Article

Memory T cells skew toward terminal differentiation in the CD8+ T cell population in patients with acute myeloid leukemia

Stem cell memory T (T_SCM) and central memory T (T_CM) cells can rapidly differentiate into effector memory (T_EM) and terminal effector (T_EF) T cells, and have the most potential for immunotherapy. In this study, w...

Ling Xu, Danlin Yao, Jiaxiong Tan, Zifan He, Zhi Yu… in Journal of Hematology & Oncology (2018)