13 Result(s)

Article

Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated retinal degeneration is not full...

Chunwen Duan, Chengcheng Ding, **hao Sun, Shengru Mao… in Stem Cell Research & Therapy (2024)

Article

Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox

Retinal pigment epithelium (RPE) cell therapy is a promising way to treat many retinal diseases. However, obtaining transplantable RPE cells is time-consuming and less effective. This study aimed to develop no...

Wenxuan Wang, Tingting Yang, Sihui Chen, Liying Liang… in Journal of Biological Engineering (2024)

Article

Cord blood-derived biologics lead to robust axonal regeneration in benzalkonium chloride-injured mouse corneas by modulating the Il-17 pathway and neuropeptide Y

Umbilical cord blood-derived therapeutics, such as serum (UCS) and platelet-rich plasma (UCPRP), are popular treatment options in clinical trials and can potentially be utilized to address a clinically unmet n...

Ruo**g Huang, Caiying Su, Na Zhang, Congying Shi, Guangming Pu… in Molecular Medicine (2024)

Article

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases

Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society, making efforts to cure blindness imperative. Transg...

Yuqin Liang, **hao Sun, Chunwen Duan, Shibo Tang… in Stem Cell Research & Therapy (2023)

Article

Sodium butyrate ameliorates diabetic retinopathy in mice via the regulation of gut microbiota and related short-chain fatty acids

Diabetic retinopathy (DR) development is associated with disturbances in the gut microbiota and related metabolites. Butyric acid is one of the short-chain fatty acids (SCFAs), which has been found to possess ...

Yinhua Huang, Zhijie Wang, Bo Ye, Jacey Hongjie MA… in Journal of Translational Medicine (2023)

Article

Dry eye syndrome: comprehensive etiologies and recent clinical trials

Dry eye syndrome (DES) is multifactorial and likely to be a cause of concern more so than ever given the rapid pace of modernization, which is directly associated with many of the extrinsic causative factors. ...

Ruo**g Huang, Caiying Su, Lvjie Fang, Jiaqi Lu, Jiansu Chen… in International Ophthalmology (2022)

Article

Correction: Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease

Deliang Zhu, Mengyuan **e, Fabian Gademann, Jixing Cao… in Stem Cell Research & Therapy (2022)

Article

Retraction Note to: WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

Shengqun Jiang, Jiansu Chen in Molecular Medicine (2021)

Article

RETRACTED ARTICLE: WRN inhibits oxidative stress-induced apoptosis of human lensepithelial cells through ATM/p53 signaling pathway and its expression is downregulated by DNA methylation

Apoptosis and oxidative stress are the main etiology of age related cataract (ARC). This article aims to investigate the role of WRN in lens epithelial cells (LECs).

Shengqun Jiang, Jiansu Chen in Molecular Medicine (2020)

Article

Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease

Retinitis pigmentosa (RP) is an inherited retinal disease characterized by progressive loss of photoreceptor cells. This study aim at exploring the effect of retinal pigment epithelium (RPE) derived from human...

Deliang Zhu, Mengyuan **e, Fabian Gademann, Jixing Cao… in Stem Cell Research & Therapy (2020)

Article

In vitro biomimetic platforms featuring a perfusion system and 3D spheroid culture promote the construction of tissue-engineered corneal endothelial layers

Corneal endothelial cells (CECs) are very important for the maintenance of corneal transparency. However, in vitro, CECs display limited proliferation and loss of phenotype via endothelial to mesenchymal transfor...

Shanyi Li, Yuting Han, Hao Lei, Yingxin Zeng, Zekai Cui… in Scientific Reports (2017)

Article

Insulin Restores an Altered Corneal Epithelium Circadian Rhythm in Mice with Streptozotocin-induced Type 1 Diabetes

The mechanisms of corneal epithelial lesions and delayed wound repair, as well as their association with diabetes mellitus, are critical issues for clinical ophthalmologists. To test whether the diabetic condi...

Fang Song, Yunxia Xue, Dong Dong, Jun Liu, Ting Fu, Chengju **ao… in Scientific Reports (2016)

Article

Mast Cells Participate in Corneal Development in Mice

The development of the cornea, a highly specialized transparent tissue located at the anterior of the eye, is coordinated by a variety of molecules and cells. Here, we report that mast cells (MCs), recently fo...

Jun Liu, Ting Fu, Fang Song, Yunxia Xue, Chaoyong **a, Peng Liu… in Scientific Reports (2015)