5 Result(s)

Article

Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease

Retinitis pigmentosa (RP) is an inherited retinal disease characterized by progressive loss of photoreceptor cells. This study aim at exploring the effect of retinal pigment epithelium (RPE) derived from human...

Deliang Zhu, Mengyuan **e, Fabian Gademann, Jixing Cao… in Stem Cell Research & Therapy (2020)

Article

Correction: Protective effects of human iPS-derived retinal pigmented epithelial cells on retinal degenerative disease

Deliang Zhu, Mengyuan **e, Fabian Gademann, Jixing Cao… in Stem Cell Research & Therapy (2022)

Article

Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases

Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable economic burden on patients and society, making efforts to cure blindness imperative. Transg...

Yuqin Liang, **hao Sun, Chunwen Duan, Shibo Tang… in Stem Cell Research & Therapy (2023)

Article

Tissue engineering RPE sheet derived from hiPSC-RPE cell spheroids supplemented with Y-27632 and RepSox

Retinal pigment epithelium (RPE) cell therapy is a promising way to treat many retinal diseases. However, obtaining transplantable RPE cells is time-consuming and less effective. This study aimed to develop no...

Wenxuan Wang, Tingting Yang, Sihui Chen, Liying Liang… in Journal of Biological Engineering (2024)

Article

Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

X-linked juvenile retinoschisis (XLRS) is an inherited disease caused by RS1 gene mutation, which leads to retinal splitting and visual impairment. The mechanism of RS1-associated retinal degeneration is not full...

Chunwen Duan, Chengcheng Ding, **hao Sun, Shengru Mao… in Stem Cell Research & Therapy (2024)