-
Article
Dendritic-cell-targeting virus-like particles as potent mRNA vaccine carriers
Messenger RNA vaccines lack specificity for dendritic cells (DCs)—the most effective cells at antigen presentation. Here we report the design and performance of a DC-targeting virus-like particle pseudotyped w...
-
Article
Open AccessStability and Function of Extracellular Vesicles Derived from Immortalized Human Corneal Stromal Stem Cells: A Proof of Concept Study
With significant advancement and development of extracellular vesicle (EV)-based therapies, there is a growing need to understand how their storage affects their physical and functional characteristics. EVs we...
-
Article
Open AccessThe relationship between corneal biomechanical parameters and treatment outcomes of orthokeratology lenses
To evaluate changes in corneal biomechanical properties after long-term orthokeratology (OK) treatment and the factors affecting treatment outcomes.
-
Article
Open AccessAnterior synechiae after penetrating keratoplasty in infants and children with Peters’ anomaly
To evaluate anterior synechiae after penetrating keratoplasty (PK) in patients with Peters’ anomaly using anterior segment optical coherence tomography (OCT).
-
Article
Open AccessIntegrative analysis of key candidate genes and signaling pathways in acute coronary syndrome related to obstructive sleep apnea by bioinformatics
Although obstructive sleep apnea (OSA) has been clinically reported to be associated with acute coronary syndrome (ACS), the pathogenesis between the two is unclear. Herein, we analyzed and screened out the pr...
-
Article
Factors predicting long-term changes in refraction after lamellar keratoscleroplasty in children with limbal dermoids
The objective of this study is to determine the factors that predict long-term changes in refraction after lamellar keratoscleroplasty in paediatric patients with limbal dermoids.
-
Article
Open AccessDeep learning for identifying corneal diseases from ocular surface slit-lamp photographs
To demonstrate the identification of corneal diseases using a novel deep learning algorithm. A novel hierarchical deep learning network, which is composed of a family of multi-task multi-label learning classif...
-
Article
Femtosecond laser-assisted Descemet’s strip** endothelial keratoplasty: a prospective study of 6-month visual outcomes, corneal thickness and endothelial cell loss
To report 6-month outcomes of visual acuity, the corneal thickness and endothelial cell density (ECD) in patients undergoing femtosecond laser-assisted Descemet’s strip** endothelial keratoplasty (FS-DSEK).
-
Article
Open AccessMalapposition of graft-host interface after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK): an optical coherence tomography study
Previous studies of internal graft-host malappositions have not dealt with the precise ways in which each malapposition affected post-penetrating keratoplasty (post-PK) visual outcomes. In this study, we revie...
-
Article
Open AccessNerve growth factor inhibits TLR3-induced inflammatory cascades in human corneal epithelial cells
In herpes simplex epithelial keratitis, excessive TLR3-induced cellular responses after virus infection evoke inflammatory cascades that might be destructive to the host cornea. Nerve growth factor (NGF), a pl...
-
Article
Evaluation of corneal cross-linking as adjuvant therapy for the management of fungal keratitis
To evaluate the efficacy of corneal cross-linking (CXL) as adjuvant therapy for the treatment of fungal ulcerative keratitis.
-
Article
Essential role of ultraviolet radiation in the decrease of corneal endothelial cell density caused by pterygium
To investigate the essential role of ultraviolet (UV) radiation in the decrease of corneal endothelial cell density (ECD) caused by pterygium.
-
Article
Open AccessFunctional relevance for central cornea thickness-associated genetic variants by using integrative analyses
The genetic architecture underlying central cornea thickness (CCT) is far from understood. Most of the CCT-associated variants are located in the non-coding regions, raising the difficulty of following functio...
-
Article
Hydroxypropyl methylcellulose 2% for dry eye prevention during phacoemulsification in senile and diabetic patients
To assess the effect of hydroxypropyl methylcellulose (HPMC) 2% to prevent dry eye during phacoemulsification in senile and diabetic patients.
-
Article
The evaluation of diagnostic efficiency for stromal herpes simplex keratitis by the combination of tear HSV-sIgA and HSV-DNA
To assess the differential diagnostic values for stromal herpes simplex keratitis (HSK) by using tear HSV-sIgA, tear HSV-DNA, and the combination.
-
Article
Open AccessMeasurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy
To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects,...
-
Article
Open AccessComparison of human corneal cell density by age and corneal location: an in vivo confocal microscopy study
Peripheral and central regions of the cornea are optically different and have different repair capacity and pathology. For this reason, we characterized the cellular morphology and quantified the cell density ...
-
Article
Open AccessAmbient air pollution, weather changes and outpatient visits for allergic conjunctivitis: A retrospective registry study
Allergic conjunctivitis is a common problem that significantly impairs patients’ quality of life. Whether air pollution serves as a risk factor for the development of allergic conjunctivitis remains elusive. I...
-
Article
Open AccessAll-trans retinoid acid promotes allogeneic corneal graft survival in mice by regulating Treg-Th17 balance in the presence of TGF-β
All-trans retinoid acid (ATRA) has been proven to skew Regulatory T cell-T helper 17 cell (Treg-Th17) balance toward Treg in vitro, favoring graft acceptance. However, its in vivo effect after solid organ transpl...
-
Article
Open AccessPseudomonas aeruginosa keratitis misdiagnosed as fungal keratitis by in vivo confocal microscopy: a case report
To report a case of non-typical Pseudomonas aeruginosa keratitis that was misdiagnosed as fungal keratitis by in vivo confocal microscopy.
