-
Chapter and Conference Paper
IvyGPT: InteractiVe Chinese Pathway Language Model in Medical Domain
General large language models (LLMs) such as ChatGPT have shown remarkable success. However, such LLMs have not been widely adopted for medical purposes, due to poor accuracy and inability to provide medical a...
-
Article
Open AccessIn-situ cryo-immune engineering of tumor microenvironment with cold-responsive nanotechnology for cancer immunotherapy
Cancer immunotherapy that deploys the host’s immune system to recognize and attack tumors, is a promising strategy for cancer treatment. However, its efficacy is greatly restricted by the immunosuppressive (i....
-
Article
Open AccessCarbon nano-onion-mediated dual targeting of P-selectin and P-glycoprotein to overcome cancer drug resistance
The transmembrane P-glycoprotein (P-gp) pumps that efflux drugs are a major mechanism of cancer drug resistance. They are also important in protecting normal tissue cells from poisonous xenobiotics and endogen...
-
Article
Author Correction: Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Publisher Correction: Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer
The Supplementary Information originally published with this Article was an older version, in which ‘IFN-γ’ was misspelled ‘INF-γ’ in Supplementary Fig. 9 and the β-Actin blot in Supplementary Fig. 13 was the ...
-
Article
Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer
TP53 is the most frequently mutated or deleted gene in triple negative breast cancer (TNBC). Both the loss of TP53 and the lack of targeted therapy are significantly correlated with poor clinical outcomes, making...
-
Article
Open AccessTargeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer
Chromosome 17q23 amplification occurs in ~11% of human breast cancers. Enriched in HER2+ breast cancers, the 17q23 amplification is significantly correlated with poor clinical outcomes. In addition to the prev...
-
Article
Open AccessBioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction
It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripote...
-
Article
Targeted anti-cancer prodrug based on carbon nanotube with photodynamic therapeutic effect and pH-triggered drug release
Herein, we describe a multifunctional anti-cancer prodrug system based on water-dispersible carbon nanotube (CNT); this prodrug system features active targeting, pH-triggered drug release, and photodynamic the...
