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Article
Open AccessCeramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2
Acute liver injury is the basis of the pathogenesis of diverse liver diseases. However, the mechanism underlying liver injury is complex and not completely understood. In our study, we revealed that CERK, whic...
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Article
Open AccessOXR1 maintains the retromer to delay brain aging under dietary restriction
Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in ...
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Article
Open AccessACS-20/FATP4 mediates the anti-ageing effect of dietary restriction in C. elegans
Dietary restriction is an effective anti-ageing intervention across species. However, the molecular mechanisms from the metabolic aspects of view are still underexplored. Here we show ACS-20 as a key mediator ...
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Article
Open AccessPulmonary fibrosis and its related factors in discharged patients with new corona virus pneumonia: a cohort study
Thousands of Coronavirus Disease 2019 (COVID-19) patients have been discharged from hospitals Persistent follow-up studies are required to evaluate the prevalence of post-COVID-19 fibrosis.
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Article
The correlation between viral clearance and biochemical outcomes of 94 COVID-19 infected discharged patients
This study aims to evaluate the correlation between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb...
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Article
Open AccessMolecular mechanisms of dietary restriction in aging—insights from Caenorhabditis elegans research
Dietary restriction (DR) is one of the most robust environmental manipulations that not only extend life span but also delay the onset of age-related diseases in almost every species examined. Caenorhabditis eleg...
