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  1. No Access

    Article

    Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

    Arachidonyl and adrenoyl PE phospholipids generated by ACSL4, an acyl-CoA synthase, are doubly or triply oxidized by lipoxygenases and other iron-containing sources of oxidation to promote ferroptotic cell death.

    Valerian E Kagan, Gaowei Mao, Feng Qu… in Nature Chemical Biology (2017)

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    Article

    Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors

    Programmed death (apoptosis) is turned on in damaged or unwanted cells to secure their clean and safe self-elimination. The initial apoptotic events are coordinated in mitochondria, whereby several proapoptoti...

    Valerian E Kagan, Vladimir A Tyurin, Jianfei Jiang… in Nature Chemical Biology (2005)