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  1. No Access

    Article

    Design, synthesis, and biological evaluation of catalpalactone and its analogs

    Ten catalpalactone derivatives were designed, synthesized, and their structures were identified by 1H NMR, 13C NMR, and HRMS. All the analogs were evaluated for antimicrobial, cytotoxic activities and insecticida...

    Jianchun Zhao, Dan Chen, **aochen Niu, Hongwei Zhang… in Medicinal Chemistry Research (2022)

  2. No Access

    Article

    Synthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities

    Deuterium substitution has been widely known that can improve the pharmacokinetic profiles due to isotope effect. Herein, a series of deuterated sorafenib derivatives have been synthesized and characterized by 1H...

    Lili Zhong, Chenhui Hou, Liang Zhang, Jianchun Zhao, Feng Li… in Molecular Diversity (2019)