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  1. No Access

    Article

    A geometry-aware multi-coordinate transformation fusion network for optic disc and cup segmentation

    The determination of potential glaucoma cases often relies on the vertical cup-to-disc ratio, which is directly derived from segmentation results. This study introduces an approach that leverages the geometric...

    Yajie Yang, Gang Yang, Yanni Wang, **nyue Liu, Jianchun Zhao… in Applied Intelligence (2024)

  2. No Access

    Chapter and Conference Paper

    Representation, Alignment, Fusion: A Generic Transformer-Based Framework for Multi-modal Glaucoma Recognition

    Early glaucoma can be diagnosed with various modalities based on morphological features. However, most existing automated solutions rely on single-modality, such as Color Fundus Photography (CFP) which lacks 3...

    You Zhou, Gang Yang, Yang Zhou, Dayong Ding… in Medical Image Computing and Computer Assis… (2023)

  3. No Access

    Article

    Design, synthesis, and biological evaluation of catalpalactone and its analogs

    Ten catalpalactone derivatives were designed, synthesized, and their structures were identified by 1H NMR, 13C NMR, and HRMS. All the analogs were evaluated for antimicrobial, cytotoxic activities and insecticida...

    Jianchun Zhao, Dan Chen, **aochen Niu, Hongwei Zhang… in Medicinal Chemistry Research (2022)

  4. No Access

    Chapter and Conference Paper

    Fundus Photograph Defect Repair Algorithm Based on Portable Camera Empty Shot

    Fundus photograph is an important basis for ophthalmologists to diagnose retinal diseases. Due to the limitations of the optical system design for portable fundus cameras, there still exist typical image defec...

    Jun Wu, Hanwen Zhang, Mingxin He, Jianchun Zhao… in Ophthalmic Medical Image Analysis (2022)

  5. No Access

    Chapter and Conference Paper

    Template Mask Based Image Fusion Built-in Algorithm for Wide Field Fundus Cameras

    When a typical wide field fundus camera takes two fundus images as a pair, two patterns of illumination beams (the top and bottom, left and right) are turned on respectively. Due to the influence of the illumi...

    Jun Wu, Mingxin He, Yang Liu, Hanwen Zhang… in Ophthalmic Medical Image Analysis (2022)

  6. No Access

    Chapter and Conference Paper

    Semi-supervised Learning for Nerve Segmentation in Corneal Confocal Microscope Photography

    Corneal nerve fiber medical indicators are promising metrics for diagnosis of diabetic peripheral neuropathy. However, automatic nerve segmentation still faces the issues of insufficient data and expensive ann...

    Jun Wu, Bo Shen, Hanwen Zhang, Jianing Wang… in Medical Image Computing and Computer Assis… (2022)

  7. No Access

    Article

    Design, synthesis, and biological evaluation of novel stachydrine derivatives as potent neuroprotective agents for cerebral ischemic stroke

    Stachydrine is a natural product with multiple protective biological activities, including those involved in preventing cancer, ischemia, and cardiovascular disease. However, its use has been limited by low bi...

    Liang Zhang, Feng Li, Chenhui Hou… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2020)

  8. No Access

    Article

    Combination of a novel microtubule inhibitor MBRI-001 and gemcitabine synergistically induces cell apoptosis by increasing DNA damage in pancreatic cancer cell lines

    Pancreatic cancer (PC) is a highly malignant cancer with poor prognosis. Although gemcitabine (GEM; 2′,2′-difluoro-deoxycytidine) has been used as the first-line chemotherapeutic agent in PC treatment for deca...

    Yuqian Liu, Ruochen Zang, Feifei Li, Chuanqin Shi… in Investigational New Drugs (2020)

  9. Article

    Open Access

    A heterotrimeric SMARCB1–SMARCC2 subcomplex is required for the assembly and tumor suppression function of the BAF chromatin-remodeling complex

    Guidong Chen, Hao Zhou, Beibei Liu, Yan Wang, Jianchun Zhao… in Cell Discovery (2020)

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  10. No Access

    Chapter and Conference Paper

    AttenNet: Deep Attention Based Retinal Disease Classification in OCT Images

    An optical coherence tomography (OCT) image is becoming the standard imaging modality in diagnosing retinal diseases and the assessment of their progression. However, the manual evaluation of the volumetric sc...

    Jun Wu, Yao Zhang, Jie Wang, Jianchun Zhao, Dayong Ding… in MultiMedia Modeling (2020)

  11. No Access

    Article

    Synthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities

    Deuterium substitution has been widely known that can improve the pharmacokinetic profiles due to isotope effect. Herein, a series of deuterated sorafenib derivatives have been synthesized and characterized by 1H...

    Lili Zhong, Chenhui Hou, Liang Zhang, Jianchun Zhao, Feng Li… in Molecular Diversity (2019)

  12. No Access

    Chapter and Conference Paper

    Two-Stream CNN with Loose Pair Training for Multi-modal AMD Categorization

    This paper studies automated categorization of age-related macular degeneration (AMD) given a multi-modal input, which consists of a color fundus image and an optical coherence tomography (OCT) image from a sp...

    Weisen Wang, Zhiyan Xu, Weihong Yu… in Medical Image Computing and Computer Assis… (2019)

  13. No Access

    Article

    Antitumor activity of the microtubule inhibitor MBRI-001 against human hepatocellular carcinoma as monotherapy or in combination with sorafenib

    MBRI-001 is a novel synthetic derivative of plinabulin. In this study, our purpose is to investigate the inhibition effects of MBRI-001 on human hepatocellular carcinoma as monotherapy or in combination with s...

    Mengyan Deng, Linna Li, Jianchun Zhao, Shoujun Yuan… in Cancer Chemotherapy and Pharmacology (2018)

  14. No Access

    Article

    Synthesis and pharmacokinetic property improvement of deuterated plinabulin 9

    Plinabulin, a potent microtubule-targeting agent, is derived from marine natural diketopiperazine ‘phenylahistin’. To develop novel plinabulin analogue that could display better pharmacokinetic properties and ...

    Jianchun Zhao, Hejuan Cheng, Tianwen Sun… in Journal of Ocean University of China (2017)

  15. No Access

    Article

    Distributions of sediments of the tidal flats in response to dynamic actions, Yangtze (Changjiang) Estuary

    Sediment samples with high spatial resolution (432 samples in total) and flow data were collected on the tidal flats in the mouth-bar region of the Yangtze Estuary. The data was collected in July 2005, July 20...

    Hong Yan, Zhijun Dai, Jiufa Li, Jianchun Zhao… in Journal of Geographical Sciences (2011)