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Article
Biochemical analysis of argyrophilic nonhistone proteins in chromosomes of plantTriticum aestivum
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Article
Effects of Acupuncture on Glycometabolic Enzymes in Multi-infarct Dementia Rats
Acupuncture has exhibited therapeutic effects on vascular dementia in our previous research. The mechanism of its anti-dementia effects involves energy metabolism. For brain cells, glucose metabolism is almost...
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Article
Hippocampal neuron loss is correlated with cognitive deficits in SAMP8 mice
The objective of this study is to examine whether neuron loss occurs in SAMP8 and whether neuron loss is correlated with cognitive deficits of these mice. Neuronal loss is considered as one of the most importa...
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Article
Age-related alteration in cerebral blood flow and energy failure is correlated with cognitive impairment in the senescence-accelerated prone mouse strain 8 (SAMP8)
Cerebrovascular dysfunction is an early pathogenic event in Alzheimer’s disease (AD) and plays a key role in the disease process. Cerebral hypoperfusion, brain glucose hypometabolism and disrupted blood–brain ...
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Article
Metformin use improves the survival of diabetic combined small-cell lung cancer patients
Metformin has been reported having potential anticancer effect on kinds of solid tumors, but its role in combined small-cell lung cancer (C-SCLC) remains indistinct. This study aimed to explore whether metform...
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Article
GPRC5A overexpression predicted advanced biological behaviors and poor prognosis in patients with gastric cancer
G protein-coupled receptor, family C, group 5, member A (GPRC5A) had received attentions for its role in carcinogenesis and prognostic values in several types of cancer. However, the functional roles of GPRC5A...
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Article
Acupuncture Improves Cerebral Microenvironment in Mice with Alzheimer’s Disease Treated with Hippocampal Neural Stem Cells
Transplantation with neural stem cells (NSCs) is a promising clinical therapy for Alzheimer’s disease (AD). However, the final fate of grafted NSCs is mainly determined by the host microenvironment. Therefore,...
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Article
Open AccessAcupuncture for patients with mild to moderate Alzheimer’s disease: a randomized controlled trial
Alzheimer’s disease (AD) is the most common cause of dementia. However, none of medical treatment can stop or reverse the underlying neurodegenerative of AD at present. Acupuncture has attracted more and more ...
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Article
Open AccessStaging laparoscopy for locally advanced gastric cancer in Chinese patients: a multicenter prospective registry study
Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regul...
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Article
BMI reduction and vitamin D insufficiency mediated osteoporosis and fragility fractures in patients at nutritional risk: a cross-sectional study
It seemed to be common sense that malnutrition was associated with osteoporosis, but there were few studies with detailed data proving that. Additionally, the association between BMI and osteoporosis was still...
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Article
Short- and Long-Term Outcomes of Endoscope-Assisted Laparoscopic Wedge Resection for Gastric Submucosal Tumors Adjacent to Esophagogastric Junction
Laparoscopic wedge resection (LWR) is used to treat gastric submucosal tumors (SMTs). However, LWR can injure the cardia if tumors are near the esophagogastric junction (EGJ), resulting in gastric stenosis. Th...
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Article
Open AccessNitrogen availability regulates topsoil carbon dynamics after permafrost thaw by altering microbial metabolic efficiency
Input of labile carbon may accelerate the decomposition of existing soil organic matter (priming effect), with the priming intensity depending on changes in soil nitrogen availability after permafrost thaw. Ho...
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Article
Open AccessWhen to Introduce Three-Dimensional Visualization Technology into Surgical Residency: A Randomized Controlled Trial
Three-dimensional (3D) reconstructed images have been increasingly applied for medical education. Although many studies have described the benefits of such applications, the best time to introduce 3D technolog...
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Article
Open AccessClinicopathological factors affecting the effect of neoadjuvant chemotherapy in patients with gastric cancer
Neoadjuvant chemotherapy is an important part of the comprehensive treatment of advanced gastric cancer (GC). The effect of neoadjuvant chemotherapy plays a key role in the prognosis of GC patients. Pathologic...
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Article
Open AccessLow urinary iodine is a protective factor of central lymph node metastasis in papillary thyroid cancer: a cross-sectional study
An abrupt increase of thyroid cancer has been witnessed paralleling the supplemented iodine intake in formerly iodine-deficient countries. And increased iodine intake has been linked to the rising incidence ra...
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Article
Open AccessOTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
OTUB2 is a deubiquitinating enzyme that contributes to tumor progression. However, the expression of OTUB2 and its prognostic importance in gastric cancer remain unclear. The expression of OTUB2 and KRT80 in G...
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Article
Open AccessCorrection: OTUB2 regulates KRT80 stability via deubiquitination and promotes tumour proliferation in gastric cancer
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Article
Open AccessCrosstalk between tumor-associated macrophages and tumor cells promotes chemoresistance via CXCL5/PI3K/AKT/mTOR pathway in gastric cancer
5-fluorouracil (5-FU)-based chemotherapy regimen has been widely used for the treatment of gastric cancer, but meanwhile the development of chemotherapeutic resistance remains a major clinical challenge. Tumor...
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Article
Open AccessDoes postoperative chemotherapy improve overall survival of patients with ypT1-2N0 cancer?
Perioperative chemotherapy combined with curative gastrectomy has been increasingly represented the standard therapeutic strategy for resectable gastric cancer (GC). However, it is still unclear whether postop...
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Article
Open AccessIdentification of SPRYD4 as a tumour suppressor predicts prognosis and correlates with immune infiltration in cholangiocarcinoma
Cholangiocarcinoma (CCA) is an aggressive solid tumour with a 5-year survival rate ranging from 7% to 20%. It is, therefore, urgent to identify novel biomarkers and therapeutic targets to improve the outcomes ...
