Skip to main content

4 Result(s)

within Jianbin Ruan Remove this filter Biomedicine Remove this filter Biomedicine, general Remove this filter Immunology Remove this filter Infectious Diseases Remove this filter

and

  1. No Access

    Article

    Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin

    Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and the concurrent release of damage-associated molecular patterns (DAMPs). Collectively, DAMPs are key determinants that ...

    Ashley J. Russo, Swathy O. Vasudevan, Santiago P. Méndez-Huergo… in Nature Immunology (2021)

  2. No Access

    Article

    FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

    Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes, which activate inflammatory caspases to process cytokines (IL-1β) and gasdermin...

    Jun Jacob Hu, **ng Liu, Shiyu **a, Zhibin Zhang, Ying Zhang… in Nature Immunology (2020)

  3. Article

    Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation

    In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels...

    Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan… in Nature Immunology (2019)

    Download PDF (483 KB) View Article

  4. No Access

    Article

    SERPINB1-mediated checkpoint of inflammatory caspase activation

    Inflammatory caspases (caspase-1, caspase-4, caspase-5 and caspase-11 (caspase-1/-4/-5/-11)) mediate host defense against microbial infections, processing pro-inflammatory cytokines and triggering pyroptosis. ...

    Youn Jung Choi, Stephanie Kim, Younho Choi, Travis B. Nielsen, Jun Yan… in Nature Immunology (2019)