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Article
Bcl-2 cleavages at two adjacent sites by different caspases promote cisplatin-induced apoptosis
The protein encoded by bcl-2 proto-oncogene plays an important role in the mitochondria-mediated apoptotic pathway. Although the general role of Bcl-2 is anti-apoptotic, previous work showed that Bcl-2 fragments ...
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Article
Open AccessEpigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate
Adipogenesis has an important role in regulating energy homeostasis in mammals. 3T3-L1 preadipocytes have been widely used as an in vitro model for analyzing the molecular mechanism of adipogenesis. Previous repo...