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  1. Article

    Open Access

    Nerve influence on the metabolism of type I and type II diabetic corneal stroma: an in vitro study

    Corneal innervation plays a major role in the pathobiology of diabetic corneal disease. However, innervation impact has mainly been investigated in the context of diabetic epitheliopathy and wound healing. Fur...

    Amy E. Whelchel, Sarah E. Nicholas, Jian-**ng Ma… in Scientific Reports (2021)

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  2. Article

    Open Access

    TRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions

    The invasion ability of glioblastoma (GBM) causes tumor cells to infiltrate the surrounding brain parenchyma and leads to poor outcomes. Transient receptor potential vanilloid 4 (TRPV4) exhibits a remarkable r...

    Wei Yang, Peng-fei Wu, Jian-xing Ma, Mao-jun Liao, Lun-shan Xu… in Scientific Reports (2020)

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  3. Article

    Open Access

    Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration

    Aberrant activation of the Wnt/β-catenin signaling pathway plays a pathogenic role in retinal inflammation and neovascularization. Here, we investigated whether circulating levels of Dickkopf-1 (DKK-1), a spec...

    Fangfang Qiu, Zhen Liu, Yue** Zhou, Jia He, Songjian Gong, Xue Bai… in Scientific Reports (2017)

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  4. Article

    Open Access

    ROS-mediated Different Homeostasis of Murine Corneal Epithelial Progenitor Cell Line under Oxidative Stress

    The role of ROS in stem cell biology has not been fully illustrated and understood. Here we compared the different responses and investigated the mechanism underlying oxidative stress induced by hydrogen perox...

    **g Zhou, Lian** Ge, Changkai Jia, **ling Zheng, Huixia Cui… in Scientific Reports (2016)

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  5. Article

    Open Access

    The Oxidant Role of 4-Hydroxynonenal in Corneal Epithelium

    4-Hydroxynonenal (4-HNE or HNE) is a main endogenous product of cellular lipid peroxidation in tissues and is reported to play pathogenic roles in eye diseases. Here we investigated the association between 4-H...

    Longlong Chen, Rongrong Zong, **g Zhou, Lian** Ge, Tong Zhou… in Scientific Reports (2015)

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  6. No Access

    Article

    Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development

    Uncontrolled canonical Wnt signalling supports colon epithelial tumour expansion and malignant transformation. Understanding the regulatory mechanisms involved is crucial for elucidating the pathogenesis of an...

    Baojun Chang, Kandice L. Tessneer, John McManus, **aolei Liu… in Nature Communications (2015)