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  1. Article

    Isoflavones and phytosterols contained in Xuezhikang capsules modulate cholesterol homeostasis in high-fat diet mice

    Xuezhikang (XZK), an extract of red yeast rice, has been widely used in traditional Chinese medicine to treat cardiovascular disease. Three fractions F1, F2 and F3 (primarily containing isoflavones, monacolins...

    Dong Feng, Jian-guo Sun, Run-bin Sun, Bing-chen Ou-Yang… in Acta Pharmacologica Sinica (2015)

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  2. Article

    Development of a novel individualized warfarin dose algorithm based on a population pharmacokinetic model with improved prediction accuracy for Chinese patients after heart valve replacement

    The gene-guided dosing strategy of warfarin generally leads to over-dose in patients at doses lower than 2 mg/kg, and only 50% of individual variability in daily stable doses can be explained. In this study, w...

    Yu-bin Zhu, **an-hua Hong, Meng Wei, **g Hu, **n Chen… in Acta Pharmacologica Sinica (2017)

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    Article

    Berberine attenuates ischemia–reperfusion injury through inhibiting HMGB1 release and NF-κB nuclear translocation

    Inflammatory damage plays an important role in cerebral ischemic pathogenesis and represents a new target for treatment of stroke. Berberine is a natural medicine with multiple beneficial biological activities...

    Jun-rong Zhu, Hai-dan Lu, Chao Guo, Wei-rong Fang… in Acta Pharmacologica Sinica (2018)

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    Article

    Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules

    Xuezhikang capsule (XZK) is a traditional Chinese medicine that contains lovastatin (Lv) for hyperlipidemia treatment, although it has fewer side effects than Lv. However, the pharmacokinetic mechanisms contri...

    Dong Feng, Chun Ge, Zhao-yi Tan, Jian-guo Sun, Yuan **e… in Acta Pharmacologica Sinica (2018)

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    Article

    The lncRNA Malat1 functions as a ceRNA to contribute to berberine-mediated inhibition of HMGB1 by sponging miR-181c-5p in poststroke inflammation

    Long non-coding RNAs (lncRNAs) have been identified as essential mediators in neurological dysfunction. Our previous study shows that berberine (BBR) hampers the nuclear-to-cytosolic translocation of high-mobi...

    Ding-wen Cao, Man-man Liu, Rui Duan, Yi-fu Tao, Jun-shan Zhou… in Acta Pharmacologica Sinica (2020)

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    Article

    Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin

    Etimicin (ETM), a fourth-generation aminoglycosides (AGs), is now widely clinically used in China due to its high efficacy and low toxicity. However, the mechanisms underlying its low nephrotoxicity and ototox...

    Lan Yao, **g-wei Zhang, Bin Chen, Ming-min Cai, Dong Feng… in Acta Pharmacologica Sinica (2020)