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Article
The combination effects of quercetin on starch and digestive enzymes reduce postprandial blood glucose in rats
Quercetin is the most abundant flavonoid found in human diet. In the present study, the effects of quercetin on postprandial hyperglycemia (PPHG) were investigated in two ways. First, the complexes of querceti...
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Article
Open AccessElaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation
Finely tuned mitogen-activated protein kinase (MAPK) signaling is important for cancer cell survival. Perturbations that push cells out of the MAPK fitness zone result in cell death. Previously, in a screen of...
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Article
Open AccessApplication of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
Non-traumatic intracerebral hemorrhage is a highly destructive intracranial disease with high mortality and morbidity rates. The main risk factors for cerebral hemorrhage include hypertension, amyloidosis, vas...
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Article
Anti-BCMA CAR-T Cell Therapy in Relapsed or Refractory Multiple Myeloma Patients with Impaired Renal Function
Anti-B cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy is effective and well-tolerated for refractory or relapsed multiple myeloma (RRMM). The purpose of the present study was to ...
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Article
Open AccessInherited Genetic Susceptibility to Nonimmunosuppressed Epstein-Barr Virus-associated T/NK-cell Lymphoproliferative Diseases in Chinese Patients
Epstein-Barr virus (EBV) T/NK-cell lymphoproliferative diseases are characterized by clonal expansion of EBV-infected T or NK cells, including chronic active EBV infection of T/NK-cell type (CAEBV+T/NK), EBV-asso...
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Open AccessErratum to: CAR T Cell Therapy for Hematological Malignancies
The article “CAR T Cell Therapy for Hematological Malignancies”, written by **n YANG, Gao-xiang WANG, Jian-feng ZHOU, was originally published electronically on the publisher’s internet portal on December 2019...
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Article
Discovery of oscillations above 200 keV in a black hole X-ray binary with Insight-HXMT
Low-frequency quasiperiodic oscillations (LFQPOs) are commonly found in black hole X-ray binaries, and their origin is still under debate. The properties of LFQPOs at high energies (above 30 keV) are closely r...
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Article
Open AccessNovel bioinformatic classification system for genetic signatures identification in diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is a spectrum of disease comprising more than 30% of non-Hodgkin lymphomas. Although studies have identified several molecular subgroups, the heterogeneous genetic backgro...
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Article
A novel procedure for 3D slope stability analysis: lower bound limit analysis coupled with block element method
This paper presents a novel rigorous procedure for assessing the lower bound of three dimensional (3D) slope stability based on the block element method. Within the framework of the lower bound theorem, a stat...
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Article
Open AccessCAR T Cell Therapy for Hematological Malignancies
As a rapidly progressing field in oncology, the adoptive transfer of T cells that have been genetically modified with chimeric antigen receptors (CARs) has shown striking efficacy in the management of hematolo...
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Article
Monitoring and Analysis of Chinese Chronic Myeloid Leukemia Patients Who Have Stopped Tyrosine Kinase Inhibitor Therapy
Discontinuation of tyrosine kinase inhibitor (TKI) therapy after achieving a persistent deep molecular response (DMR) is an urgently needed treatment goal for chronic myeloid leukemia (CML) patients and has be...
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Article
Dynamic and Static Combination Method for Fracture-Vug Unit Division of Fractured-Vuggy Reservoirs
Ying Mai-2 Block of Tarim Oil Field is a karst fractured-vuggy reservoir. Along with the research on well location demonstration and recovery ratio improvement in the develo** progress, the importance of fra...
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Article
Open AccessC/EBPβ enhances platinum resistance of ovarian cancer cells by reprogramming H3K79 methylation
Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics plays a pivotal role in regulating the malignant phenotype, and has the potential in develo** therapeutically valua...
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Article
Exploring the Relationship Between Serum and Urinary Free Light Chain Levels During the Different Phases of Renal Damage in Multiple Myeloma Patients
The objective was to explore the relationship between the levels of serum and urinary free light chains (FLCs) during the progression of renal damage in multiple myeloma (MM) patients. We examined 91 cases of...
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Article
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma
Zhu Chen, Sai-Juan Chen, Wei-Li Zhao and colleagues identify recurrent loss-of-function mutations in the RNA helicase gene DDX3X in 20% of subjects with natural killer/T-cell lymphoma (NKTCL) in their study. The ...
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Article
Microwave-assisted, methanesulfonic acid-catalyzed synthesis of 3,3′-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones)
Efficient synthesis of 3,3′-(arylmethylene)bis(4-hydroxy-2H-chromen-2-ones) has been achieved by methanesulfonic acid-catalyzed, microwave-assisted reaction of 4-hydroxycoumarin and aromatic aldehydes in ethanol....
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Article
Open AccessSTAT3 mutations are frequent in T-cell large granular lymphocytic leukemia with pure red cell aplasia
T-cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder and can cooccur in the context of pure red cell aplasia (PRCA). The aim of the current study was to analyze the signal...
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Article
Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel
Hec1, a member of the Ndc80 kinetochore complex, is highly expressed in cancers. The aim of this study was to explore the role and mechanism of action of Hec1 with respect to the cytotoxicity of paclitaxel in ...
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Article
Open AccessA facile one-pot, three-component synthesis of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives under microwave irradiation
A series of 3,3′-(4-arylpyridine-2,6-diyl)bis(2H-chromen-2-one) derivatives have been synthesized by the one-pot, three-component reaction of 3-acetylcoumarin, an aromatic aldehyde, and ammonium acetate in acetic...
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Article
Open AccessExperimental and theoretical study on the synthesis of gold nanoparticles using ceftriaxone as a stabilizing reagent for and its catalysis for dopamine
Electrochemical synthesis of gold nanoparticles on the surface of glassy carbon electrode and preparation of GNPs in aqueous solution using ceftriaxone as an innocuous stabilizing reagent were proposed. The go...
