1,635 Result(s)
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Jian-** Cao
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Article
Prediction and analysis of paroxysmal impulse vibration in aero-engine inter-shaft bearings induced by localized faults in the outer ring
Inter-shaft bearings, critical components within aero-engine dual-rotor systems, are susceptible to localized faults due to their unique installation locations. This research delves into a distinctive dynamic ...
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Open AccessIntegrative metagenomic, transcriptomic, and proteomic analysis reveal the microbiota-host interplay in early-stage lung adenocarcinoma among non-smokers
The incidence of early-stage lung adenocarcinoma (ES-LUAD) is steadily increasing among non-smokers. Previous research has identified dysbiosis in the gut microbiota of patients with lung cancer. However, the ...
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Open AccessIncreased ONECUT2 induced by Helicobacter pylori promotes gastric cancer cell stemness via an AKT-related pathway
Helicobacter pylori (HP) infection initiates and promotes gastric carcinogenesis. ONECUT2 shows promise for tumor diagnosis, prognosis, and treatment. This study explored ONECUT2’s role and the specific mechanism...
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Open AccessHarnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subty**
The effective isolation of rare target cells, such as circulating tumor cells, from whole blood is still challenging due to the lack of a capturing surface with strong target-binding affinity and non-target-ce...
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Host preference and mortality caused by the parasitoid Sclerodermus guani on different cerambycid species
Parasitoids of wood borers and bark beetles rarely encounter different host species simultaneously in nature, so whether they exhibit any preferences for particular species, and the relative suitability of dif...
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End-supporter path scheduling for robot-assisted asymmetrical support machining of thin-walled parts with non-equal thickness and closed section
As a typical thin-walled workpiece with non-equal thickness and closed section, the steam turbine blade is easy to be deformed and to chatter in the machining process due to its low stiffness, which seriously ...
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Open AccessClinical efficacy and identification of factors confer resistance to afatinib (tyrosine kinase inhibitor) in EGFR-overexpressing esophageal squamous cell carcinoma
Epidermal growth factor receptor (EGFR) is reportedly overexpressed in most esophageal squamous cell carcinoma (ESCC) patients, but anti-EGFR treatments offer limited survival benefits. Our preclinical data sh...
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Open AccessNicotinate-curcumin improves NASH by inhibiting the AKR1B10/ACCα-mediated triglyceride synthesis
Nonalcoholic steatohepatitis (NASH) is a prevalent chronic liver condition. However, the potential therapeutic benefits and underlying mechanism of nicotinate-curcumin (NC) in the treatment of NASH remain unce...
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Article
Molecular docking-aided AIEgen design: concept, synthesis and applications
Aggregate-induced emission luminogens (AIEgens) have been widely used in biological imaging, chemical sensing, and disease treatments. The rational design and construction of AIEgens have received considerable...
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Open AccessThe effect of cadre–farmer relationship on farmers’ willingness to treat domestic waste: evidence from China
The construction of an ecologically livable rural environment requires treating rural domestic waste. Farmers, as key participants in rural domestic waste disposal, can improve the rural environment by disposi...
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Open AccessDUSP5 regulated by YTHDF1-mediated m6A modification promotes epithelial-mesenchymal transition and EGFR-TKI resistance via the TGF-β/Smad signaling pathway in lung adenocarcinoma
Lung adenocarcinoma (LUAD) patients have a dismal survival rate because of cancer metastasis and drug resistance. The study aims to identify the genes that concurrently modulate EMT, metastasis and EGFR-TKI re...
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Open AccessTunlametinib (HL-085) plus vemurafenib in patients with advanced BRAF V600-mutant solid tumors: an open-label, single-arm, multicenter, phase I study
Tunlametinib (HL-085) is a novel, highly selective MEK inhibitor with substantial clinical activities in patients with NRAS-mutant melanoma. This phase I study evaluated the safety and preliminary efficacy of tun...
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Article
Experimental quantum computational chemistry with optimized unitary coupled cluster ansatz
Quantum computational chemistry has emerged as a potential application of quantum computing. Hybrid quantum-classical computing methods, such as variational quantum eigensolvers, have been designed as promisin...
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Open AccessAuthor Correction: A genetically encoded ratiometric indicator for tryptophan
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Open AccessHeterogeneous peer effects of college roommates on academic performance
Understanding how student peers influence learning outcomes is crucial for effective education management in complex social systems. The complexities of peer selection and evolving peer relationships, however,...
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Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial final results
Claudin18.2 (CLDN18.2) is highly expressed with the development of various malignant tumors, especially gastrointestinal cancers, and is emerging as a new target for cancer treatment. Satricabtagene autoleucel...
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Regulation of Ti(C,N) deposition on hot surface of refractory in blast furnace hearth
Ti(C,N) concentration was found to be lower on the hearth sidewall of a blast furnace and increased gradually toward the bottom of the blast furnace. The Ti(C,N) protective layer in a blast furnace is thin. Th...
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Open AccessCELSR3 is a prognostic marker in HNSCC and correlates with immune cell infiltration in the tumor microenvironment
To look at the diagnostic value of the CELSR receptor 3 (CELSR3) gene in head and neck squamous cell carcinoma (HNSCC) and its effect on tumor immune invasion, which is important for enhancing HNSCC treatment.
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Hollow Multishelled Structure: Synthesis Chemistry and Application
Hollow multishelled structure (HoMS), a promising and complex multifunctional structural system, features at least two shells that are separated by internal voids. The unique structure endows it with numerous ...
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Surface-induced Microstructure and Performance Changes in P3HT Ultrathin Films
In this work, poly(3-hexylthiophene) (P3HT) ultrathin films (P3HT-T) were prepared by spin-coating a dilute P3HT solution (in a toluene: o-dichlorobenzene (Tol:ODCB) blend with a volume ratio of 80:20) with ultra...
