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  1. No Access

    Article

    Mediation effect of antithrombin III between chronic renal insufficiency and chronic coronary artery disease in T2DM patients

    The study aimed to investigate the potential effect of Antithrombin III (ATIII) between chronic renal insufficiency and chronic coronary artery disease (chronic CAD) in type 2 diabetes mellitus (T2DM) patients.

    Ruoyu Sun, Jianhong Jia, Shaohua Wang, Zheng Wang, Chenchen Wang, Yanchao Xu in Endocrine (2024)

  2. No Access

    Article

    Polygenic Risk Score Reveals Genetic Heterogeneity of Alzheimer’s Disease between the Chinese and European Populations

    The polygenic risk score (PRS) aggregates the effects of numerous genetic variants associated with a condition across the human genome and may help to predict late-onset Alzheimer’s disease (LOAD). Most of the...

    F. Li, S. **e, J. Cui, Y. Li, T. Li, Y. Wang in The Journal of Prevention of Alzheimer's D… (2024)

  3. Article

    Open Access

    The association of regional block with intraoperative opioid consumption in patients undergoing video-assisted thoracoscopic surgery: a single-center, retrospective study

    Regional block, such as thoracic epidural analgesia (TEA), thoracic paravertebral block (TPVB), or serratus anterior plane block (SAPB) has been recommended to reduce postoperative opioid use in recent guideli...

    Yan **ang, Liang Chen, Jiang Jia, Fu Yili in Journal of Cardiothoracic Surgery (2024)

  4. Article

    Open Access

    Correction: Cost-effectiveness analysis of digital therapeutics for home-based cardiac rehabilitation for patients with chronic heart failure: model development and data analysis

    Tianyi Liu, Yiyang Zhan, Silei Chen in Cost Effectiveness and Resource Allocation (2024)

  5. No Access

    Article

    Multi-modality radiomics model predicts axillary lymph node metastasis of breast cancer using MRI and mammography

    We aimed to develop a multi-modality model to predict axillary lymph node (ALN) metastasis by combining clinical predictors with radiomic features from magnetic resonance imaging (MRI) and mammography (MMG) in...

    Qian Wang, Yingyu Lin, Cong Ding, Wenting Guan, **aoling Zhang in European Radiology (2024)

  6. Article

    Open Access

    Cellular senescence contributes to mechanical ventilation-induced diaphragm dysfunction by upregulating p53 signalling pathways

    Mechanical ventilation can cause acute atrophy and injury in the diaphragm, which are related to adverse clinical results. However, the underlying mechanisms of ventilation-induced diaphragm dysfunction (VIDD)...

    Weimin Shen, Ye Jiang, Ying Xu, **aoli Qian, Jianwei Jia in BMC Pulmonary Medicine (2023)

  7. Article

    Open Access

    Increasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery

    Major adverse cardiovascular events (MACE) are critical complications responsible for the morbidity and mortality of elderly hip fracture patients. There was an urgent need to explore an effect biomarker for p...

    Zhengtao Sun, Kai Cheng, Guochao **, Jian Jia in BMC Musculoskeletal Disorders (2023)

  8. Article

    Open Access

    Cost-effectiveness analysis of digital therapeutics for home-based cardiac rehabilitation for patients with chronic heart failure: model development and data analysis

    In recent years, numerous guidelines and expert consensus have recommended the inclusion of digital technologies and products in cardiac rehabilitation. Digital therapeutics (DTx) is an evidence-based medicine...

    Tianyi Liu, Yiyang Zhan, Silei Chen in Cost Effectiveness and Resource Allocation (2023)

  9. No Access

    Article

    Optimization of Strategy for Modified mRNA Inducing Cardiac-Specific Expression in Mice

    Lipid nanoparticle (LNP)-coated-modified RNA(modRNA) has been developed for enhancing the stability of modRNA, but it tends to accumulate in liver. The current study aimed to optimize strategy for increasing c...

    Chenxing Huang, Jianguo Jia, Kejia ** in Journal of Cardiovascular Translational Re… (2023)

  10. Article

    Open Access

    Aberrant palmitoylation caused by a ZDHHC21 mutation contributes to pathophysiology of Alzheimer’s disease

    The identification of pathogenic mutations in Alzheimer’s disease (AD) causal genes led to a better understanding of the pathobiology of AD. Familial Alzheimer’s disease (FAD) is known to be associated with mu...

    Wenwen Li, Yana Pang, Yan Wang, Fan Mei, Mengmeng Guo, Yi** Wei in BMC Medicine (2023)

  11. No Access

    Article

    CD27 agonism coordinates with CD28 and 4-1BB signal to augment the efficacy of CAR-T cells in colorectal tumor

    Chimeric antigen receptor T cell (CAR-T) is regarded as a promising therapy for malignancies. In our previous clinical trial targeted colorectal tumors, we found that CAR-T cells experienced poor proliferation...

    Chengcheng Zhang, Jiankun Jia, Gang Heng, Yunyan Li, Meilin Wang in Medical Oncology (2023)

  12. Article

    Open Access

    PEEP application during mechanical ventilation contributes to fibrosis in the diaphragm

    Positive end-expiratory airway pressure (PEEP) is a potent component of management for patients receiving mechanical ventilation (MV). However, PEEP may cause the development of diaphragm remodeling, making it...

    **aoli Qian, Ye Jiang, Jianwei Jia, Weimin Shen, Yuejia Ding in Respiratory Research (2023)

  13. Article

    Open Access

    Robotic guidance for percutaneous placement of triangular osteosynthesis in vertically unstable sacrum fractures: a single-center retrospective study

    To evaluate the effectiveness and safety of robot-aided percutaneous triangular osteosynthesis combined with close reduction for vertically unstable sacrum fractures (VUSFs).

    Zhao-Jie Liu, Ya Gu, Jian Jia in Journal of Orthopaedic Surgery and Research (2023)

  14. Article

    Open Access

    Comparative retrospective study of triangular osteosynthesis with and without robotic assistance for unilateral unstable sacral fractures combined with lumbosacral junction injuries

    To compare the clinical efficacy of unilateral unstable sacral fractures (USFs) involving the lumbosacral region treated with and without robot-aided triangular osteosynthesis (TOS).

    Zhao-Jie Liu, Ya Gu, Jian Jia in BMC Surgery (2022)

  15. Article

    Open Access

    The Kocher-Langenbeck approach combined with robot-aided percutaneous anterior column screw fixation for transverse-oriented acetabular fractures: a retrospective study

    Transverse-oriented acetabular fractures (TOAFs), including transverse, transverse with posterior wall and T-shaped fractures, are always challenging for double-column reduction and fixation with minimally inv...

    Zhao-jie Liu, Ya Gu, Jian Jia in BMC Musculoskeletal Disorders (2022)

  16. Article

    Open Access

    Astragalus mongholicus Bunge and Panax notoginseng formula (A&P) improves renal mesangial cell damage in diabetic nephropathy by inhibiting the inflammatory response of infiltrated macrophages

    Diabetic nephropathy (DN) is one of the main causes of end-stage renal disease with scantly effective treatment. Numerous evidences indicated that macrophages play an important role in the occurrence and patho...

    **ao Lin, **ao-qin Lei, Jie-ke Yang, Jian Jia in BMC Complementary Medicine and Therapies (2022)

  17. Article

    Open Access

    Development and validation of the nomogram based on INR and eGFR for estimation of mortality in patients with acute-on-chronic hepatitis B liver failure

    Acute-on-chronic hepatitis B liver failure (ACHBLF) is a critical clinical syndrome with a high short-term mortality evolved from chronic hepatitis B (CHB)-related liver disease. Prediction of mortality risk a...

    Shengnan Li, **ehua Zhang, Qian Li, Binyue Lv, Yefan Zhang in BMC Gastroenterology (2021)

  18. Article

    Open Access

    The effect of selective cerebral perfusion on cerebral versus somatic tissue oxygenation during aortic coarctation repair in neonates and infants

    Suboptimal tissue perfusion and oxygenation may be the root cause of certain perioperative complications in neonates and infants having complicated aortic coarctation repair. Practical, effective, and real-tim...

    Li Zhang, Lu Liu, Zhiqiu Zhong, Hengfang **, Jian Jia in BMC Anesthesiology (2021)

  19. No Access

    Article

    Correlative investigation between routine clinical parameters of dual-energy computed tomography and the outcomes of extracorporeal shock wave lithotripsy in children with urolithiasis: a retrospective study

    To evaluate the associations of DECT parameters with extracorporeal shock wave lithotripsy (ESWL) outcomes in pediatric patients.

    Beiwu Tu, Jianye Jia, Lengwei Yu, Huimin Li, Dengbin Wang in Abdominal Radiology (2021)

  20. Article

    Open Access

    Health seeking behavior and associated factors among individuals with cough in Yiwu, China: a population-based study

    Previous studies have shown that a certain proportion of the population did not seek medical treatment after coughing, and understanding the potential reasons is crucial for disease prevention and control.

    **aoyan Sun, Shuying Luo, Lingqiao Lou, Hang Cheng, Zhen Ye in BMC Public Health (2021)

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