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Article
Orally administered BZL-sRNA-20 oligonucleotide targeting TLR4 effectively ameliorates acute lung injury in mice
The global COVID-19 pandemic emerged at the end of December 2019. Acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) are common lethal outcomes of bacterial lipopolysaccharide (LPS), avian ...
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Article
Open AccessAvian influenza viruses suppress innate immunity by inducing trans-transcriptional readthrough via SSU72
Innate immunity plays critical antiviral roles. The highly virulent avian influenza viruses (AIVs) H5N1, H7N9, and H5N6 can better escape host innate immune responses than the less virulent seasonal H1N1 virus...
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Article
Erratum to: Herbal decoctosome is a novel form of medicine
Following the published article, we noticed an error duplication in Figure 5G “control” and “PGY-6” that was introduced during the revised process, with an attempt to replace it with higher-resolution images. ...
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Article
Open AccessSoft three-dimensional network materials with rational bio-mimetic designs
Many biological tissues offer J-shaped stress–strain responses, since their microstructures exhibit a three-dimensional (3D) network construction of curvy filamentary structures that lead to a bending-to-stret...
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Article
Herbal decoctosome is a novel form of medicine
Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs (sRNAs) were reported as a new cla...
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Article
Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7
Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RN...
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Article
Open AccessmiRNA-200c-3p is crucial in acute respiratory distress syndrome
Influenza infection and pneumonia are known to cause much of their mortality by inducing acute respiratory distress syndrome (ARDS), which is the most severe form of acute lung injury (ALI). Angiotensin-conver...
