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Article
Open AccessAlterations of Sphingolipid Metabolism in Different Types of Polycystic Ovary Syndrome
The roles of sphingolipids in polycystic ovary syndrome (PCOS) are still unknown. This study aimed to investigate the sphingolipid characteristics for different types of PCOS using liquid chromatography-mass s...
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Article
Open AccessLC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain
Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a cr...
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Article
Open AccessNew Immunosuppressive Sphingoid Base and Ceramide Analogues in Wild Cordyceps
A comprehensive identification of sphingoid bases and ceramides in wild Cordyceps was performed by integrating a sequential chromatographic enrichment procedure and an UHPLC-ultrahigh definition-Q-TOF-MS based...
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Article
Open AccessLC-MS Based Sphingolipidomic Study on A2780 Human Ovarian Cancer Cell Line and its Taxol-resistant Strain
Drug resistance elicited by cancer cells continue to cause huge problems world-wide, for example, tens of thousands of patients are suffering from taxol-resistant human ovarian cancer. However, its biochemical...
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Article
Open AccessQuantitative profiling of sphingolipids in wild Cordyceps and its mycelia by using UHPLC-MS
In the present study, 101 sphingolipids in wild Cordyceps and its five mycelia were quantitatively profiled by using a fully validated UHPLC-MS method. The results revealed that a general rank order for the ab...
