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The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin

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  1. Article

    Open Access

    DOK3 maintains intestinal homeostasis by suppressing JAK2/STAT3 signaling and S100a8/9 production in neutrophils

    How pathogenesis of inflammatory bowel disease (IBD) depends on the complex interplay of host genetics, microbiome and the immune system is not fully understood. Here, we showed that Downstream of Kinase 3 (DO...

    Jia Tong Loh, Koon-Guan Lee, Alison P. Lee, Joey Kay Hui Teo… in Cell Death & Disease (2021)

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  2. Article

    Open Access

    Host-derived lipids orchestrate pulmonary γδ T cell response to provide early protection against influenza virus infection

    Innate immunity is important for host defense by eliciting rapid anti-viral responses and bridging adaptive immunity. Here, we show that endogenous lipids released from virus-infected host cells activate lung ...

    **aohui Wang, **ang Lin, Zihan Zheng, Bingtai Lu, Jun Wang… in Nature Communications (2021)

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  3. Article

    Open Access

    Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution

    Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast c...

    Hwa Hwa Chung, Yu Zuan Or, Smeeta Shrestha, Jia Tong Loh… in Scientific Reports (2017)

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