G Protein-Coupled Receptors
Immobilization and Applications in Drug Discovery
Page
%P
-
Article
DIffuse X-ray Explorer: A High-Resolution X-ray Spectroscopic Sky Surveyor on the China Space Station
DIffuse X-ray Explorer (DIXE) is a proposed high-resolution X-ray spectroscopic sky surveyor on the China Space Station (CSS). DIXE will focus on studying hot baryons in the Milky Way. Galactic hot baryons lik...
-
Chapter and Conference Paper
Analysis of the Performance Difference Between4He and 3He in Space JT Cryocoolers
Joule-Thomson (JT) cryocoolers play an essential role in space exploration missions. The JT cryocoolers with different working fluids have different operating temperatures. 4He and 3He are used in JT coolers to o...
-
Chapter
Immobilized GPCRs in Drug-Receptor Interaction Analysis
The development of new assays for understanding GPCR-drug interaction has witnessed many breakthroughs during the last decades. Since then, a number of additional examples of new approaches and/or applications...
-
Chapter
Purification of G Protein-Coupled Receptors
Apart from the singular exception of rhodopsin, GPCRs are naturally poorly abundant in the human body. As such, producing milligram amounts of purified, active, and stable GPCRs is not trivial and has long bee...
-
Chapter
Key Biochemical Aspects of Drug-Target Interactions
The realization of drug-target interaction plays important role in many processes that determine the fate of a drug and its eventual therapeutic effects in practice. This makes it critical to fundamental resea...
-
Chapter
Immobilized GPCRs in Compound Screening
Screening the bioactive compounds targeting GPCRs is a pre-requisite step for the development of new drugs associated with the receptor. Synthetic compound libraries and natural product extracts are the widely...
-
Chapter
G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) are important drug targets for FDA-approved drugs. Understanding the biology, structure, and pharmacology of GPCRs is of paramount importance for drug discovery. This chapte...
-
Chapter
Oriented Immobilization of G Protein-Coupled Receptors
GPCR immobilization is fundamental for many bioanalytical methods, which are crucial for receptor-ligand interaction analysis and drug discovery. A desirable way to immobilize GPCRs on solid surfaces is orient...
-
Book
-
Article
Cucurbit[7]uril as a Broad-Spectrum Antiviral Agent against Diverse RNA Viruses
The emergence and re-emergence of RNA virus outbreaks highlight the urgent need for the development of broad-spectrum antivirals. Polyamines are positively-charged small molecules required for the infectivity ...
-
Article
A Brief Review of Dilution Refrigerator Development for Space Applications
The open-cycle dilution refrigerator (OCDR) has been successfully applied on the Planck mission because it doesn’t need a magnetic field and can continuously provide cooling power. However, the short lifetime ...
-
Article
A closed loop 2.65 K hybrid JT cooler for future space application
-
Article
Identification of MGMT promoter methylation sites correlating with gene expression and IDH1 mutation in gliomas
O6-methylguanine-DNA methyltransferase (MGMT) gene promoter methylation was reported to be an independent prognostic and predictive factor in glioma patients who received temozolomide treatment. However, the pred...
-
Article
A miniature liquid helium temperature JT cryocooler for space application
Along with the development of space science and technology, miniature liquid helium temperature long life cryocooler is a focus subject in cryogenic study. Since it is the precondition of space detection resea...
-
Article
4 K high frequency pulse tube cryocooler used for terahertz space application
Terahertz (THz) frequency region, defined from 0.1 to 10 THz, is an important frequency band for radio astronomy and atmospheric science. As NbN Superconductor-Insulator-Superconductor (SIS) mixers used for te...
-
Article
Assessment of the effectiveness of nature reserve management in China
Assessing the management effectiveness of nature reserves is an effective way to promote management quality and achieve management targets. Using a questionnaire developed by the World Bank (WB) and the World ...
