15 Result(s)

Article

Author Correction: Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype

Ji-chun Zhang, Wei Yao, Youge Qu, Mayumi Nakamura, Chao Dong… in Scientific Reports (2023)

Article

Serine/threonine kinase TBK1 promotes cholangiocarcinoma progression via direct regulation of β-catenin

Cholangiocarcinoma (CCA) is a highly heterogeneous and metastatic malignancy with a poor prognosis even after curative hepatectomy. Studies exploring its pathogenesis and identifying effective therapeutic targ...

Chong-Qing Gao, Zhen-Zhen Chu, Di Zhang, Yang **ao, **ng-Yan Zhou, Jun-Ru Wu… in Oncogene (2023)

Article

Nrf2 regulates the arginase 1⁺ microglia phenotype through the initiation of TREM2 transcription, ameliorating depression-like behavior in mice

The expression of the triggering receptor on myeloid cell-2 (TREM2) knockdown in microglia from the lateral habenula (LHb) reportedly induces depression-like behaviors in mice. However, the key molecular mecha...

Lujuan He, Yi Zheng, Lixuan Huang, **gyi Ye, Yinyi Ye… in Translational Psychiatry (2022)

Article

Regulation of BDNF transcription by Nrf2 and MeCP2 ameliorates MPTP-induced neurotoxicity

Mounting evidence suggests the key role of brain-derived neurotrophic factor (BDNF) in the dopaminergic neurotoxicity of Parkinson’s disease (PD). Activation of NF-E2-related factor-2 (Nrf2) and inhibition of ...

Qianqian Cao, Qiuming Zou, **n Zhao, Yimin Zhang, Youge Qu… in Cell Death Discovery (2022)

Article

Correction: Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

Wei Yao, Qianqian Cao, Shilin Luo, Lujuan He, Chun Yang, Jiaxu Chen… in Molecular Psychiatry (2022)

Article

Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine

(R,S)-ketamine elicits rapid-acting and sustained antidepressant actions in treatment-resistant patients with depression. (R)-ketamine produces longer-lasting antidepressant effects than (S)-ketamine in rodents; ...

Wei Yao, Qianqian Cao, Shilin Luo, Lujuan He, Chun Yang, Jiaxu Chen… in Molecular Psychiatry (2022)

Article

Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents

The transcription factor erythroid 2-related factor 2 (Nrf2) and brain-derived neurotrophic factor (BDNF) play a key role in depression. However, the molecular mechanisms underlying the crosstalk between Nrf2 ...

Wei Yao, Song Lin, ** Su, Qianqian Cao, Yueyue Chen… in Translational Psychiatry (2021)

Article

Increased EphA4-ephexin1 signaling in the medial prefrontal cortex plays a role in depression-like phenotype

Accumulating evidence suggests a role of the ephrin receptor EphA4 and the downstream protein ephexin1 in synaptic plasticity, which is implicated in depression. We examined whether EphA4–ephexin1 signaling pl...

Ji-chun Zhang, Wei Yao, Youge Qu, Mayumi Nakamura, Chao Dong… in Scientific Reports (2017)

Article

Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

Addition of low doses of atypical antipsychotic drugs with selective serotonin reuptake inhibitors (SSRIs) could promote a rapid antidepressant effect in treatment-resistant patients with major depression. Bre...

Min Ma, Qian Ren, Chun Yang, Ji-chun Zhang, Wei Yao, Chao Dong… in Psychopharmacology (2017)

Article

Adjunctive treatment of brexpiprazole with fluoxetine shows a rapid antidepressant effect in social defeat stress model: Role of BDNF-TrkB signaling

Addition of low doses of the atypical antipsychotic drug brexpiprazole with selective serotonin reuptake inhibitors (SSRIs) could promote antidepressant effect in patients with major depressive disorder althou...

Min Ma, Qian Ren, Chun Yang, Ji-chun Zhang, Wei Yao, Chao Dong… in Scientific Reports (2016)

Article

Depression-like phenotype by deletion of α7 nicotinic acetylcholine receptor: Role of BDNF-TrkB in nucleus accumbens

The α7 subtype of nicotinic acetylcholine receptor (nAChR) plays a role in the inflammation which is implicated in depression. This study was undertaken to examine the role of α7 nAChR in depression using α7 n...

Ji-chun Zhang, Wei Yao, Qian Ren, Chun Yang, Chao Dong, Min Ma… in Scientific Reports (2016)

Article

Intake of 7,8-Dihydroxyflavone During Juvenile and Adolescent Stages Prevents Onset of Psychosis in Adult Offspring After Maternal Immune Activation

Prenatal infection and subsequent abnormal neurodevelopment of offspring is involved in the etiology of schizophrenia. Brain-derived neurotrophic factor (BDNF) and its high affinity receptor, tropomyosin recep...

Mei Han, Ji-chun Zhang, Wei Yao, Chun Yang, Tamaki Ishima, Qian Ren… in Scientific Reports (2016)

Article

Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

The N-methyl-d-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal models of depression.

Bangkun Yang, Ji-chun Zhang, Mei Han, Wei Yao, Chun Yang, Qian Ren… in Psychopharmacology (2016)

Article

Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice

The transcription factor Keap1-Nrf2 system plays a key role in inflammation which is involved in depression. We found lower expression of Keap1 and Nrf2 proteins in the prefrontal cortex (PFC), CA3 and dentate...

Wei Yao, Ji-chun Zhang, Tamaki Ishima, Chao Dong, Chun Yang, Qian Ren… in Scientific Reports (2016)

Article

In vivo tracking of human placenta derived mesenchymal stem cells in nude mice via ¹⁴C-TdR labeling

In order to shed light on the regenerative mechanism of mesenchymal stem cells (MSCs) in vivo, the bio-distribution profile of implanted cells using a stable and long-term tracking method is needed. We herein inv...

Cheng-Guang Wu, Ji-Chun Zhang, Cheng-Quan **e, Ornella Parolini… in BMC Biotechnology (2015)