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  1. No Access

    Article

    18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype

    18β-glycyrrhetinic acid (18β-GA) has been reported to have anti-inflammatory and neuroprotective effects. However, the therapeutic effect of 18β-GA in Parkinson’s disease (PD) has not been defined.

    Hanyue Luo, Caishi Zhang, Lujuan He, Zefang Lin, Ji-chun Zhang, Qi Qi… in Psychopharmacology (2023)

  2. No Access

    Article

    Lipopolysaccharide-induced endotoxaemia during adolescence promotes stress vulnerability in adult mice via deregulation of nuclear factor erythroid 2-related factor 2 in the medial prefrontal cortex

    Sepsis is a severe inflammatory response to infection that leads to long-lasting cognitive impairment and depression after resolution. The lipopolysaccharide (LPS)-induced endotoxaemia model is a well-establi...

    Yan-chen Chen, Yan-hua Huang, Li Song, **ao-han Tong, Jun-feng Li… in Psychopharmacology (2023)

  3. No Access

    Article

    The role of MeCP2 and the BDNF/TrkB signaling pathway in the stress resilience of mice subjected to CSDS

    There is accumulating evidence to support the idea that brain-derived neurotrophic factor (BDNF) is involved in stress resilience. However, the precise molecular mechanisms underlying resilience in major depre...

    Lixuan Huang, Lujuan He, Ruijia Ma, Wanzhao Ding, Chan Zhou, Song Lin… in Psychopharmacology (2022)

  4. No Access

    Article

    Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription

    Sulforaphane (SFN) is an organic isothiocyanate and an NF-E2-related factor-2 (Nrf2) inducer that exerts prophylactic effects on depression-like behavior in mice. However, the underlying mechanisms remain poor...

    Rui Tang, Qian-qian Cao, Sheng-wei Hu, Lu-juan He… in Acta Pharmacologica Sinica (2022)

  5. No Access

    Article

    NRG1 accelerates the forgetting of fear memories and facilitates the induction of long-term depression in adult mice

    Forgetting of fear memory is a current medical therapy for posttraumatic stress disorder (PTSD), and hippocampal long-term depression (LTD) may be the underlying mechanism. Neuregulin 1 (NRG1), a trophic facto...

    Qianqian Cao, Yuan Wei, Jialin Deng, Junfeng Li, Yanhua Huang… in Psychopharmacology (2021)

  6. Article

    Open Access

    Antidepressant effects of combination of brexpiprazole and fluoxetine on depression-like behavior and dendritic changes in mice after inflammation

    Addition of low doses of atypical antipsychotic drugs with selective serotonin reuptake inhibitors (SSRIs) could promote a rapid antidepressant effect in treatment-resistant patients with major depression. Bre...

    Min Ma, Qian Ren, Chun Yang, Ji-chun Zhang, Wei Yao, Chao Dong… in Psychopharmacology (2017)

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  7. Article

    Open Access

    Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression

    The N-methyl-d-aspartate (NMDA) receptor antagonists, including R-ketamine and rapastinel (formerly GLYX-13), show rapid antidepressant effects in animal models of depression.

    Bangkun Yang, Ji-chun Zhang, Mei Han, Wei Yao, Chun Yang, Qian Ren… in Psychopharmacology (2016)

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  8. No Access

    Article

    Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression

    Brain-derived neurotrophic factor (BDNF) and signaling at its receptor, tropomyosin-related kinase B (TrkB), are implicated in the rapid and long-lasting antidepressant effects of ketamine. Moreover, a TrkB ag...

    Ji-chun Zhang, Wei Yao, Chao Dong, Chun Yang, Qian Ren, Min Ma… in Psychopharmacology (2015)

  9. No Access

    Article

    7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine

    It is widely recognized that methamphetamine (METH) induces behavioral abnormalities and dopaminergic neurotoxicity in the brain. Several lines of evidence suggest a role for brain-derived neurotrophic factor ...

    Qian Ren, Ji-Chun Zhang, Min Ma, Yuko Fujita, ** Wu, Kenji Hashimoto in Psychopharmacology (2014)