6 Result(s)

Article

A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery

SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far. Due to the high infectivity and pathogenicity of this virus, all studies on the live virus are strictl...

Yun-Yun **, Hanwen Lin, Liu Cao, Wei-Chen Wu, Yanxi Ji, Liubing Du… in Virologica Sinica (2021)

Article

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex. We employed a mammalian two-h...

Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin… in Cell & Bioscience (2021)

Article

PTEN suppresses tumorigenesis by directly dephosphorylating Akt

Lang Bu, Huan Wang, Ji-an Pan, Lang Chen… in Signal Transduction and Targeted Therapy (2021)

Article

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through ...

Panpan Hou, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li… in Cell Research (2021)

Article

SARS-CoV nucleocapsid protein antagonizes IFN-β response by targeting initial step of IFN-β induction pathway, and its C-terminal region is critical for the antagonism

Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a highly basic nucleocapsid (N) protein which can inhibit the synthesis of type I interferon (IFN), but the molecular mechanism of this antagoni...

**aolu Lu, Ji’an Pan, Jiali Tao, Deyin Guo in Virus Genes (2011)

Chapter and Conference Paper

Identification and Characterization of Severe Acute Respiratory Syndrome Coronavirus Subgenomic RNAs

Snawar Hussain, Ji'an Pan, **g Xu, Yalin Yang, Yu Chen, Yu Peng… in The Nidoviruses (2006)