58 Result(s)

Article

Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions

**angpeng Sheng, Fang Zhu, Hong Peng, Fan Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Individual bat virome analysis reveals co-infection and spillover among bats and virus zoonotic potential

Bats are reservoir hosts for many zoonotic viruses. Despite this, relatively little is known about the diversity and abundance of viruses within individual bats, and hence the frequency of virus co-infection a...

**g Wang, Yuan-fei Pan, Li-fen Yang, Wei-hong Yang, Kexin Lv… in Nature Communications (2023)

Article

Distinct and relatively mild clinical characteristics of SARS-CoV-2 BA.5 infections against BA.2

Li** Guo, Xue Liu, Yuchen Gu, **yan Jiang… in Signal Transduction and Targeted Therapy (2023)

Article

Preclinical characterization and anti-SARS-CoV-2 efficacy of ATV014: an oral cyclohexanecarboxylate prodrug of 1′-CN-4-aza-7,9-dideazaadenosine C-nucleoside

Qifan Zhou, Sidi Yang, Liu Cao, Yang Yang… in Signal Transduction and Targeted Therapy (2023)

Article

USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID

Activation-induced cytidine deaminase (AID) initiates class-switch recombination and somatic hypermutation (SHM) in antibody genes. Protein expression and activity are tightly controlled by various mechanisms....

Yuewen Luo, **antao Zhang, Ran Chen, Rong Li… in Signal Transduction and Targeted Therapy (2022)

Article

Correction: Autophagy receptor CCDC50 modulates STING-mediated interferon response in viral infection and autoimmune disease

Panpan Hou, Yuxin Lin, Zibo Li, Ruiqing Lu, Yicheng Wang… in Cellular & Molecular Immunology (2021)

Article

Safety and Considerations of the COVID-19 Vaccine Massive Deployment

Junwei Li, Mingyue Song, Deyin Guo, Yongxiang Yi in Virologica Sinica (2021)

Article

A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery

SARS-CoV-2 causes the pandemic of COVID-19 and no effective drugs for this disease are available thus far. Due to the high infectivity and pathogenicity of this virus, all studies on the live virus are strictl...

Yun-Yun **, Hanwen Lin, Liu Cao, Wei-Chen Wu, Yanxi Ji, Liubing Du… in Virologica Sinica (2021)

Article

Endogenous reverse transcriptase and RNase H-mediated antiviral mechanism in embryonic stem cells

Nucleic acid-based systems play important roles in antiviral defense, including CRISPR/Cas that adopts RNA-guided DNA cleavage to prevent DNA phage infection and RNA interference (RNAi) that employs RNA-guided...

Junyu Wu, Chunyan Wu, Fan **ng, Liu Cao, Weijie Zeng, Li** Guo, ** Li… in Cell Research (2021)

Article

Modulating the tumor microenvironment via oncolytic virus and PI3K inhibition synergistically restores immune checkpoint therapy response in PTEN-deficient glioblastoma

Fan **ng, **gshu **ao, Junyu Wu, Jiaming Liang… in Signal Transduction and Targeted Therapy (2021)

Article

Genome-wide analysis of protein–protein interactions and involvement of viral proteins in SARS-CoV-2 replication

Analysis of viral protein–protein interactions is an essential step to uncover the viral protein functions and the molecular mechanism for the assembly of a viral protein complex. We employed a mammalian two-h...

Yiling Jiang, Kuijie Tong, Roubin Yao, Yuanze Zhou, Hanwen Lin… in Cell & Bioscience (2021)

Article

PTEN suppresses tumorigenesis by directly dephosphorylating Akt

Lang Bu, Huan Wang, Ji-an Pan, Lang Chen… in Signal Transduction and Targeted Therapy (2021)

Article

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq

B cell response plays a critical role against SARS-CoV-2 infection. However, little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infectio...

Bing He, Shuning Liu, Yuanyuan Wang, Mengxin Xu… in Signal Transduction and Targeted Therapy (2021)

Article

Global analysis of HBV-mediated host proteome and ubiquitylome change in HepG2.2.15 human hepatoblastoma cell line

Hepatitis B virus (HBV) infection remains a major health issue worldwide and the leading cause of cirrhosis and hepatocellular carcinoma (HCC). It has been reported previously that HBV invasion can extensively...

Sen Yuan, Yousaf Tanzeel, Xuezhang Tian, Dandan Zheng, Naz Wajeeha… in Cell & Bioscience (2021)

Article

A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection

Autophagy is a conserved process that delivers cytosolic substances to the lysosome for degradation, but its direct role in the regulation of antiviral innate immunity remains poorly understood. Here, through ...

Panpan Hou, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li… in Cell Research (2021)

Article

Old Weapon for New Enemy: Drug Repurposing for Treatment of Newly Emerging Viral Diseases

Deyin Guo in Virologica Sinica (2020)