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  1. Article

    Open Access

    The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma

    The TINCR (Terminal differentiation-Induced Non-Coding RNA) gene is selectively expressed in epithelium tissues and is involved in the control of human epidermal differentiation and wound healing. Despite its ini...

    Lucia Morgado-Palacin, Jessie A. Brown, Thomas F. Martinez… in Nature Communications (2023)

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    Article

    Epigenetic reversal of hematopoietic stem cell aging in Phf6-knockout mice

    Aging is characterized by an accumulation of myeloid-biased hematopoietic stem cells (HSCs) with reduced developmental potential. Genotoxic stress and epigenetic alterations have been proposed to mediate age-r...

    Agnieszka A. Wendorff, S. Aidan Quinn, Silvia Alvarez, Jessie A. Brown… in Nature Aging (2022)

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    Article

    Mutational and functional genetics map** of chemotherapy resistance mechanisms in relapsed acute lymphoblastic leukemia

    Multiagent combination chemotherapy can be curative in acute lymphoblastic leukemia (ALL). Still, patients with primary refractory disease or with relapsed leukemia have a very poor prognosis. Here we integrat...

    Koichi Oshima, Junfei Zhao, Pablo Pérez-Durán, Jessie A. Brown… in Nature Cancer (2020)