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Article
Open AccessGlucose phosphate isomerase deficiency demasked by whole-genome sequencing: a case report
Glucose-6-phosphate isomerase deficiency is a rare genetic disorder causing hereditary nonspherocytic hemolytic anemia. It is the second most common glycolytic enzymopathy in red blood cells. About 90 cases ar...
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Article
Priapism in patients with hemolytic disorders: a nationwide retrospective cohort study
Priapism is a persistent, painful erection, which can lead to permanent penile damage and reduced quality of life. Patients with sickle cell disease have an increased risk of priapism which has been related to...
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Article
Open AccessCardiac arrhythmias and electrolyte disturbances in colic horses
Despite increased focus on cardiac arrhythmias in horses, the nature and prevalence is still poorly described. Case reports suggest that arrhythmias occurring secondary to systemic disease are seen more common...
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Article
Open AccessClinical recovery of two hip adductor longus ruptures: a case-report of a soccer player
Non-operative treatment of acute hip adductor longus ruptures in athletes has been described in the literature. However, very limited information concerning the recovery of this type of injury exists. This cas...
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Article
Short-term street soccer improves fitness and cardiovascular health status of homeless men
This study examined the effect of 12 weeks of small-sided street soccer (2.2 ± 0.7 sessions/week) and fitness center training (0.5 ± 0.2 sessions/week) on physical fitness and cardiovascular health profile for...
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Article
Microfluidic DNA microarrays in PMMA chips: streamlined fabrication via simultaneous DNA immobilization and bonding activation by brief UV exposure
This report presents and describes a simple and scalable method for producing functional DNA microarrays within enclosed polymeric, PMMA, microfluidic devices. Brief (30 s) exposure to UV simultaneously immobi...
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Article
Increasing the specificity and function of DNA microarrays by processing arrays at different stringencies
DNA microarrays have for a decade been the only platform for genome-wide analysis and have provided a wealth of information about living organisms. DNA microarrays are processed today under one condition only,...
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Article
Open AccessSumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers
Triptans are effective and well tolerated in acute migraine management but their exact mechanism of action is still debated. Triptans might exert their antimigraine effect by reducing the levels of circulating...
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Protocol
Target Preparation for Genoty** Specific Genes or Gene Segments
Generation of single stranded target is of high importance for hybridization reactions on oligonucleotide microarrays. Several methods have been established for production of single stranded DNA and in vitro t...
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Protocol
Genoty** of Mutations in the Beta-Globin Gene Using Allele Specific Hybridization
The use of DNA microarrays for genoty** is economically favorable when compared to real-time PCR and DNA sequencing. Here, we demonstrate a DNA microarray-based assay using allele-specific oligonucleotide (A...
