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  1. Article

    Open Access

    CRISPR-mediated generation and characterization of a Gaa homozygous c.1935C>A (p.D645E) Pompe disease knock-in mouse model recapitulating human infantile onset-Pompe disease

    Pompe disease, an autosomal recessive disorder caused by deficient lysosomal acid α-glucosidase (GAA), is characterized by accumulation of intra-lysosomal glycogen in skeletal and oftentimes cardiac muscle. Th...

    Shih-hsin Kan, Jeffrey Y. Huang, Jerry Harb, Allisandra Rha… in Scientific Reports (2022)

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    Article

    A double-blinded placebo-controlled evaluation of adipose-derived mesenchymal stem cells in treatment of canine atopic dermatitis

    Mesenchymal stem cells (MSCs) have emerged as a new therapy for various immune-mediated inflammatory diseases. In this study we perform the first double-blinded, placebo-controlled evaluation of the efficacy o...

    Gagandeep Kaur, Ana Ramirez, Chen **e, David Clark… in Veterinary Research Communications (2022)

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    Article

    Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

    Review current understanding of both canonical and non-canonical Wnt signaling in cancer and provide updated knowledge in current clinical trials of Wnt signaling drugs.

    Jerry Harb, Pen-Jen Lin, Jijun Hao in Current Oncology Reports (2019)