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Article
Open AccessNicotine exposure decreases likelihood of SARS-CoV-2 RNA expression and neuropathology in the hACE2 mouse brain but not moribundity
Individuals infected by SARS-CoV-2 are at risk of develo** neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find expos...
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Article
Loss of α7 nicotinic acetylcholine receptors in GABAergic neurons causes sex-dependent decreases in radial glia-like cell quantity and impairments in cognitive and social behavior
The dentate gyrus (DG) is a unique brain structure in that neurons can be generated postnatally and integrated within existing circuitry throughout life. The maturation process of these newly generated neurons...
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Article
Open AccessA novel role of NLRP3-generated IL-1β in the acute-chronic transition of peripheral lipopolysaccharide-elicited neuroinflammation: implications for sepsis-associated neurodegeneration
Sepsis-associated acute brain inflammation, if unresolved, may cause chronic neuroinflammation and resultant neurodegenerative diseases. However, little is known how the transition from acute to chronic neuroi...
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Article
A subset of noradrenergic (NE) neurons defined by developmental expression of Hoxb1 have a distinct role in attenuating the behavioral response to acute stress
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Article
Genetic identification of a population of noradrenergic neurons implicated in attenuation of stress-related responses
Noradrenergic signaling plays a well-established role in promoting the stress response. Here we identify a subpopulation of noradrenergic neurons, defined by developmental expression of Hoxb1, that has a unique r...
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Article
The α7 nicotinic acetylcholine receptors regulate hippocampal adult-neurogenesis in a sexually dimorphic fashion
Disruption in cholinergic signaling has been linked to many environmental and/or pathological conditions known to modify adult neurogenesis. The α7 nAChRs are in the family of cys-loop receptor channels which ...
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Article
Local cholinergic-GABAergic circuitry within the basal forebrain is modulated by galanin
The basal forebrain (BF) is an important regulator of hippocampal and cortical activity. In Alzheimer’s disease (AD), there is a significant loss and dysfunction of cholinergic neurons within the BF, and also ...
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Article
Inducing theta oscillations in the entorhinal hippocampal network in vitro
The hippocampal theta rhythm emerges as rhythmic and synchronized activities among the hippocampus and hippocampus-associated brain regions during active exploration, providing a potential means for inter-regi...
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Article
A mutation in the extracellular domain of the α7 nAChR reduces calcium permeability
The α7 neuronal nicotinic acetylcholine receptor (nAChR) displays the highest calcium permeability among the different subtypes of nAChRs expressed in the mammalian brain and can impact cellular events includi...
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Article
Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease
The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability throughout the nervous system by acting on both the cys-loop ligand-gated nicotinic ACh receptor channels (nAChRs) and the G protein-...
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Article
Functional α7 Nicotinic ACh Receptors on Astrocytes in Rat Hippocampal CA1 Slices
Although much is known about the functional expression of the neuronal nicotinic acetylcholine receptors (nAChRs) in various neuronal populations in the brain and elsewhere, much less is known about their expr...
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Article
Allosteric Modulator Desformylflustrabromine Relieves the Inhibition of α2β2 and α4β2 Nicotinic Acetylcholine Receptors by β-Amyloid1–42 Peptide
Nicotinic acetylcholine receptors (nAChRs) are pentameric transmembrane proteins that belong to the cys-loop ligand-gated ion channel family. These receptors are widely expressed in the brain and implicated in...
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Article
Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system
Based on the composition of the five subunits forming functional neuronal nicotinic acetylcholine receptors (nAChRs), they are grouped into either heteromeric (comprising both α and β subunits) or homomeric (c...
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Article
Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by β-amyloid1–42 peptide
Neuronal nicotinic acetylcholine receptors (nAChRs) are involved in a variety of physiological processes, including cognition and development. Dysfunctions in nAChRs have been linked to Alzheimer’s disease (AD...
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Article
Inhibitory interneurons in hippocampus
In the hippocampus and DG, a small number of morphologically and physiologically diverse interneurons controls the neuronal activity of large numbers of the principal excitatory output cells. The inhibitory in...
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Protocol
Functional Study of Glutamate Receptor Channels in Brain Slices
Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). Glutamate binds to and activates receptors coupled to both ligand-gated ion channels (ionotropic) and G proteins (metabot...
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Article
Inactivation of the Ba2+ current in dissociated Helix neurons: voltage dependence and the role of phosphorylation
The rate of inactivation of the voltage-dependent Ba2+ current in dissociated neurons from the snail Helix aspersa was found to be modulated by phosphorylation. Conditions were chosen such that the most likely me...
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Chapter
Cytoplasmic Modulation of Transmitter Gated K Channels in Cultured Mammalian Central Neurons
Recent years have seen considerable progress in our understanding of slow inhibitory synaptic processes in the mammalian brain. In many studies a surprisingly similar mechanism of inhibition has emerged, thoug...
