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Article
Open AccessAuthor Correction: Enhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
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Article
Open AccessEnhancer hijacking at the ARHGAP36 locus is associated with connective tissue to bone transformation
Heterotopic ossification is a disorder caused by abnormal mineralization of soft tissues in which signaling pathways such as BMP, TGFβ and WNT are known key players in driving ectopic bone formation. Identifyi...
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Article
Open AccessFKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 ...
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Article
Open AccessA versatile Halo- and SNAP-tagged BMP/TGFβ receptor library for quantification of cell surface ligand binding
TGFβs, BMPs and Activins regulate numerous developmental and homeostatic processes and signal through hetero-tetrameric receptor complexes composed of two types of serine/threonine kinase receptors. Each of th...
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Article
Open AccessAtheroprone fluid shear stress-regulated ALK1-Endoglin-SMAD signaling originates from early endosomes
Fluid shear stress enhances endothelial SMAD1/5 signaling via the BMP9-bound ALK1 receptor complex supported by the co-receptor Endoglin. While moderate SMAD1/5 activation is required to maintain endothelial q...
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Article
Open AccessIRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation
Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulato...
