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Article
Obesity increases the odds of intervertebral disc herniation and spinal stenosis; an MRI study of 1634 low back pain patients
The objective of this study was to examine the relationships between BMI and intervertebral disc degeneration (DD), disc herniation (DH) and spinal stenosis (SS) using a large, prospectively recruited and hete...
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Chapter and Conference Paper
3D Shape Analysis of Scoliosis
Scoliosis is typically measured in 2D in the coronal plane, although it is a three-dimensional (3D) condition. Our objective in this work is to analyse the 3D geometry of the spine and its relationship to the ...
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Article
Open AccessConsensus on a standardised treatment pathway algorithm for lumbar spinal stenosis: an international Delphi study
Lumbar spinal stenosis (LSS) is a common degenerative spinal condition in older adults associated with disability, diminished quality of life, and substantial healthcare costs. Individual symptoms and needs va...
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Article
Open AccessCorrection to: Identifying Scoliosis in Population‑Based Cohorts: Automation of a Validated Method Based on Total Body Dual Energy X‑ray Absorptiometry Scans
In the original version of the article, the co-author would like to add to the acknowledgements section to highlight their funding stream (EPSRC). The revised acknowledgements is given below.
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Article
Open AccessIdentifying Scoliosis in Population-Based Cohorts: Automation of a Validated Method Based on Total Body Dual Energy X-ray Absorptiometry Scans
Scoliosis is a 3D-torsional rotation of the spine, but risk factors for initiation and progression are little understood. Research is hampered by lack of population-based research since radiographs cannot be p...
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Article
Open AccessCould automated machine-learned MRI grading aid epidemiological studies of lumbar spinal stenosis? Validation within the Wakayama spine study
MRI scanning has revolutionized the clinical diagnosis of lumbar spinal stenosis (LSS). However, there is currently no consensus as to how best to classify MRI findings which has hampered the development of ro...
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Article
Open AccessMulticentre, double-blind, randomised, sham-controlled trial of 10 khz high-frequency spinal cord stimulation for chronic neuropathic low back pain (MODULATE-LBP): a trial protocol
Chronic neuropathic low back pain (CNLBP) is a debilitating condition in which established medical treatments seldom alleviate symptoms. Evidence demonstrates that high-frequency 10 kHz spinal cord stimulation...
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Article
Systematic review of the complications associated with magnetically controlled growing rods for the treatment of early onset scoliosis
To analyse the complication profile of magnetically controlled growing rods (MCGRs) in early onset scoliosis (EOS).
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Article
Comment on “Do we have the right PROMs for measuring outcomes in lumbar spinal surgery?” by O. M. Stokes et al. Eur Spine J. 2017 Mar;26(3):816–824
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Article
Open AccessA self-organising biomimetic collagen/nano-hydroxyapatite-glycosaminoglycan scaffold for spinal fusion
The use of spinal fusion surgery as a treatment for degenerative spinal conditions and chronic back pain is increasing. However, this technique requires use of a bone grafting material to fuse the vertebrae, ...
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Article
Erratum to: The diagnosis and management of infection following instrumented spinal fusion
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Article
Open AccessISSLS PRIZE IN BIOENGINEERING SCIENCE 2017: Automation of reading of radiological features from magnetic resonance images (MRIs) of the lumbar spine without human intervention is comparable with an expert radiologist
Investigation of the automation of radiological features from magnetic resonance images (MRIs) of the lumbar spine.
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Article
Infection and low back pain: seeking evidence or fear of exploring new indications for antibiotics?
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Article
Open AccessDisc herniations in astronauts: What causes them, and what does it tell us about herniation on earth?
Recent work showed an increased risk of cervical and lumbar intervertebral disc (IVD) herniations in astronauts. The European Space Agency asked the authors to advise on the underlying pathophysiology of this ...
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Article
Age and pro-inflammatory gene polymorphisms influence adjacent segment disc degeneration more than fusion does in patients treated for chronic low back pain
Does lumbar fusion lead to accelerated adjacent segment disc degeneration (ASDD) or is it explained by genetics and aging? The influence of genetics on ASDD remains to be explored. This study assesses whether ...
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Article
Catechol-O-methyltransferase (COMT) gene polymorphisms are associated with baseline disability but not long-term treatment outcome in patients with chronic low back pain
To examine the association between COMT and OPRM1 gene polymorphisms and pain and disability at baseline and long-term follow-up in patients treated for chronic low back pain (LBP).
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Article
Advances in the diagnosis of degenerated lumbar discs and their possible clinical application
One possible source of chronic low back pain is a degenerated intervertebral disc. In this review, various diagnostic methods for the assessment of the presence of degenerative changes are described. These inc...
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Article
Disc degeneration-related clinical phenotypes
The phenotype, or observable trait of interest, is at the core of studies identifying associated genetic variants and their functional pathways, as well as diagnostics. Yet, despite remarkable technological de...
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Article
Reliability and validity study on the Hungarian versions of the Oswestry Disability Index and the Quebec Back Pain Disability Scale
Patient-reported outcome measurements (PROMs) are widely used in spine care. The development of reliable and valid National versions of spine-related disability questionnaires is strongly recommended from both...
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Article
Open AccessSurgeons and scientists: symbiosis in spinal research?
