7 Result(s)
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Jeremiah Bernier-Latmani
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Article
Open AccessADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
The small intestinal villus tip is the first point of contact for lumen-derived substances including nutrients and microbial products. Electron microscopy studies from the early 1970s uncovered unusual spatial...
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Article
Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth
Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth fact...
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Article
Open AccessLoss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures
Tertiary lymphoid structures (TLS) are lymph node-like immune cell clusters that emerge during chronic inflammation in non-lymphoid organs like the kidney, but their origin remains not well understood. Here we...
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Article
Intestinal lymphatic vasculature: structure, mechanisms and functions
Intestinal lymphatic vessels are critical for fat absorption and gut immunosurveillance
Some of the molecul...
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Article
High-resolution 3D analysis of mouse small-intestinal stroma
This protocol describes how to perform whole-mount immunostaining and imaging on adult mouse small-intestinal villi. All gut cell types can be seen at high resolution and in 3D without the need for image recon...
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Article
Open AccessStability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium
The signalling pathways operational in quiescent, post-development vasculature remain enigmatic. Here we show that unlike neovascularization, endothelial Akt signalling in established vasculature is crucial no...
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Chapter
Development and Differentiation of the Lymphatic Vascular System
The lymphatic vasculature is critical for the maintenance of homeostasis, and performs essential roles in the trafficking of fluids, immune cells, and dietary fats. This importance is highlighted by the contri...
