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Article
Effects of telmisartan and perindopril combination on hypertension and cardiovascular damage
Combined therapy is considered when monotherapy fails to control blood pressure (BP). This study evaluated the effects of combined treatment with telmisartan (an angiotensin receptor blocker, ARB) and perindop...
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Article
Cream formulation improved skin-lightening effect of ginsenoside Rh1, Rg2, and Hydrangea macrophylla flower extract
The aim of this study was to evaluate the synergistic effect of ginsenoside Rh1, Rg2, and Hydrangea extract on skin-lightening and to assess the skin-lightening effect of cream formulation containing these three ...
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Article
Solid dispersion of mebendazole via surfactant carrier to improve oral bioavailability and in vitro anticancer efficacy
This study aimed to prepare a solid dispersion (SD) formulation of MBZ to improve dissolution and oral bioavailability.
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Article
Intratympanic drug delivery systems to treat inner ear impairments
Sensorineural hearing loss (SNHL) is a disorder that significantly affects human quality of life. Current treatment for SNHL is still limited to hearing aids and cochlear implants. A better understanding of th...
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Article
Space Sterilization Effect Through High-Density Plasma Ozone Using DBD Device
Atmospheric pressure plasma is generated via electrical discharge under atmospheric pressure, and the electron energy is generally higher than that of other particles such as ions and neutral particles. In thi...
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Article
Alginate-coated chitosan nanoparticles protect protein drugs from acid degradation in gastric media
The aim of this study was to design and evaluate chitosan nanoparticles (CS NPs) coated with alginate which protect protein drugs from acid degradation.K The model protein drug used was bovine serum albumin (B...
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Article
Recent trends of self-emulsifying drug delivery system for enhancing the oral bioavailability of poorly water-soluble drugs
The oral route is the most popular route for the clinical administration of drugs to treat various diseases. Before a drug is absorbed into the blood circulation, it must undergo dissolution and permeation. Ho...
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Article
Recent advances of nanotechnology for the delivery of anticancer drugs for breast cancer treatment
Breast cancer is one of the most common causes of death for women worldwide. While chemotherapy is the treatment option for most cancers, surgery, chemotherapy, and radiotherapy are the three main therapeutic ...
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Article
Solubility enhancement and application of cyclodextrins in local drug delivery
Cyclodextrins (CDs) have been used in many pharmaceutical formulations as their constitution and inherent shape present advantages for drugs with poor aqueous solubility and low bioavailability. Because CDs ca...
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Article
Recent formulation approaches to oral delivery of herbal medicines
The well-known anticancer agent, paclitaxel, is a naturally occurring diterpenoid from Taxus brevifolia. It is an effective antineoplastic agent that has been widely used for the treatment of various cancers, inc...
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Article
Preparation and physicochemical characterization of ketoprofen-loaded emulsions
The objective of this study was to prepare ketoprofen-loaded emulsions. The emulsions were formulated by mixing soybean oil, surfactants (a mixture of Tween 20 and Tween 80), and distilled water. To determine ...
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Article
Simultaneous analysis of ibuprofen and pamabrom by HPLC
A selective and simple HPLC method was developed for ibuprofen (IBF) and pamabrom (PAMB) from in bulk and drug product using the same conditions, which was operated on a reverse phase (C18 column) with water (60 ...
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Article
Preformulation and in vitro physicochemical characterization of fenofibrate-loaded emulsion
The objective of this study was to prepare a fenofibrate-loaded emulsion. The emulsion was formulated by mixing olive oil, surfactants (mixture of Tween 20 and Tween 80), and distilled water. To find the emuls...
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Article
Determination of preparation parameters for albendazole-loaded nanoparticles using chitosan and tripolyphosphate
Albendazole is poorly soluble in water and has low bioavailability. The objective of this study was to improve the solubility of albendazole and optimize preparation of an oral nanoparticle formulation, using ...
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Article
Preparation and characterization of mucoadhesive enteric-coating ginsenoside-loaded microparticles
Ginsenoside saponins are phytochemically extracted from red ginseng and have been regarded as the principal components manifesting the pharmacologic activities. Saponins are very soluble in water but poorly ab...
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Article
Preliminary study to determine the optimal conditions for the simultaneous complexation of siRNA and plasmid DNA
We investigated the complexation ratio of siRNA and plasmid DNA combined with Lipofectamine for the effective delivery of genetic materials. First, the amount of Lipofectamine was varied with a fixed amount of...
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Article
Preparation and characterization of isosorbide 5-mononitrate extended-release tablets
The objective of this study was to prepare isosorbide 5-mononitrate tablets with an extended-release base using paraffin wax. The goal was to develop a tablet formulation equivalent to the commercially availab...
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Article
Formulation parameters influencing the physicochemical characteristics of rosiglitazone-loaded cationic lipid emulsion
To enhance the solubility of rosiglitazone, rosiglitazone-loaded cationic lipid emulsion was formulated using cationic lipid DOTAP, DOPE, castor oil, tween 20, and tween 80. The formulation parameters in terms...
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Article
Enhanced effect of losartan and rosuvastatin on neointima hyperplasia
The beneficial effects of losartan and rosuvastatin on neointimal formation have been well characterized, but little is known about the combined treatment benefit of these two drugs. This study was designed to...
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Article
Thermo-reversible flurbiprofen liquid suppository with HP-β-CD as a solubility enhancer: improvement of rectal bioavailability
The purpose of this work was to develop a thermo-reversible flurbiprofen liquid suppository base composed of poloxamer and sodium alginate for the improvement of rectal bioavailability of flurbiprofen. Cyclode...
