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Article
Open AccessIntegrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA
Multi-cancer early detection remains a key challenge in cell-free DNA (cfDNA)-based liquid biopsy. Here, we perform cfDNA whole-genome sequencing to generate two test datasets covering 2125 patient samples of ...
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Article
Open AccessClinical outcomes of colonoscopic polypectomy with strategic surveillance colonoscopies in patients with 10 or more polyps
The clinical usefulness of repeat colonoscopic polypectomy in patients with numerous polyps has not been sufficiently determined. We aimed to analyze the clinical outcomes of colonoscopic polypectomy with surv...
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Article
Open AccessBiomolecular imaging of colorectal tumor lesions using a FITC-labeled scFv-Cκ fragment antibody
For the sensitive diagnosis of colorectal cancer lesions, advanced molecular imaging techniques using cancer-specific targets have emerged. However, issues regarding the clearance of unbound probes and immunog...
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Article
Open AccessAnchoring the snare tip is a feasible endoscopic mucosal resection method for small rectal neuroendocrine tumors
Small rectal neuroendocrine tumors (NETs) can be treated using cap-assisted endoscopic mucosal resection (EMR-C), which requires additional effort to apply a dedicated cap and snare. We aimed to evaluate the f...
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Article
Open AccessEndoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients
We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients ...
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Article
Open AccessMachine learning approach for differentiating cytomegalovirus esophagitis from herpes simplex virus esophagitis
The endoscopic features between herpes simplex virus (HSV) and cytomegalovirus (CMV) esophagitis overlap significantly, and hence the differential diagnosis between HSV and CMV esophagitis is sometimes difficu...
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Article
Open AccessRisk of postpolypectomy bleeding in patients taking direct oral anticoagulants or clopidogrel
The usage of direct oral anticoagulants (DOACs) to prevent and treat thromboembolic events is gradually increasing. We aimed to evaluate the outcomes of patients taking DOACs after polypectomy. We retrospectiv...
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Article
Open AccessReal-time detection of colon polyps during colonoscopy using deep learning: systematic validation with four independent datasets
We developed and validated a deep-learning algorithm for polyp detection. We used a YOLOv2 to develop the algorithm for automatic polyp detection on 8,075 images (503 polyps). We validated the algorithm using ...
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Article
Open AccessEndoscopic diagnosis and treatment planning for colorectal polyps using a deep-learning model
We aimed to develop a computer-aided diagnostic system (CAD) for predicting colorectal polyp histology using deep-learning technology and to validate its performance. Near-focus narrow-band imaging (NBI) pictu...
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Article
Open AccessImmunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance
Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple imm...
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Article
Open AccessEndoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats
Owing to the recent progress in regenerative medicine technology, clinical trials that harnessed the regeneration and immune modulation potentiality of stem cells for treating IBD have shown promising results....
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Article
Open AccessElevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease
Few studies have been conducted on the progression of mild Crohn’s disease (CD). We aimed to investigate the natural course in mild CD patients with or without bowel damage, to identify predictors of bowel res...