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  1. Article

    Open Access

    Integrative modeling of tumor genomes and epigenomes for enhanced cancer diagnosis by cell-free DNA

    Multi-cancer early detection remains a key challenge in cell-free DNA (cfDNA)-based liquid biopsy. Here, we perform cfDNA whole-genome sequencing to generate two test datasets covering 2125 patient samples of ...

    Mingyun Bae, Gyuhee Kim, Tae-Rim Lee, ** Mo Ahn, Hyunwook Park in Nature Communications (2023)

  2. Article

    Open Access

    Clinical outcomes of colonoscopic polypectomy with strategic surveillance colonoscopies in patients with 10 or more polyps

    The clinical usefulness of repeat colonoscopic polypectomy in patients with numerous polyps has not been sufficiently determined. We aimed to analyze the clinical outcomes of colonoscopic polypectomy with surv...

    ** Hwa Park, Seung Wook Hong, Sung Wook Hwang, Sang Hyoung Park in Scientific Reports (2023)

  3. Article

    Open Access

    Biomolecular imaging of colorectal tumor lesions using a FITC-labeled scFv-Cκ fragment antibody

    For the sensitive diagnosis of colorectal cancer lesions, advanced molecular imaging techniques using cancer-specific targets have emerged. However, issues regarding the clearance of unbound probes and immunog...

    Hyung Il Kim, **hyeon Kim, Hyori Kim, Hyeri Lee, Yong Sik Yoon in Scientific Reports (2021)

  4. Article

    Open Access

    Anchoring the snare tip is a feasible endoscopic mucosal resection method for small rectal neuroendocrine tumors

    Small rectal neuroendocrine tumors (NETs) can be treated using cap-assisted endoscopic mucosal resection (EMR-C), which requires additional effort to apply a dedicated cap and snare. We aimed to evaluate the f...

    Jeongseok Kim, Jisup Kim, Eun Hye Oh, Nam Seok Ham, Sung Wook Hwang in Scientific Reports (2021)

  5. Article

    Open Access

    Endoscopic features and clinical outcomes of cytomegalovirus gastroenterocolitis in immunocompetent patients

    We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients ...

    Jiyoung Yoon, Junghwan Lee, Dae Sung Kim, ** Wook Lee in Scientific Reports (2021)

  6. Article

    Open Access

    Machine learning approach for differentiating cytomegalovirus esophagitis from herpes simplex virus esophagitis

    The endoscopic features between herpes simplex virus (HSV) and cytomegalovirus (CMV) esophagitis overlap significantly, and hence the differential diagnosis between HSV and CMV esophagitis is sometimes difficu...

    Jung Su Lee, Jihye Yun, Sungwon Ham, Hyunjung Park, Hyunsu Lee in Scientific Reports (2021)

  7. Article

    Open Access

    Risk of postpolypectomy bleeding in patients taking direct oral anticoagulants or clopidogrel

    The usage of direct oral anticoagulants (DOACs) to prevent and treat thromboembolic events is gradually increasing. We aimed to evaluate the outcomes of patients taking DOACs after polypectomy. We retrospectiv...

    Gwang-Un Kim, Sinwon Lee, Jaewon Choe, Sung Wook Hwang in Scientific Reports (2021)

  8. Article

    Open Access

    Real-time detection of colon polyps during colonoscopy using deep learning: systematic validation with four independent datasets

    We developed and validated a deep-learning algorithm for polyp detection. We used a YOLOv2 to develop the algorithm for automatic polyp detection on 8,075 images (503 polyps). We validated the algorithm using ...

    Ji Young Lee, **hoon Jeong, Eun Mi Song, Chunae Ha, Hyo Jeong Lee in Scientific Reports (2020)

  9. Article

    Open Access

    Endoscopic diagnosis and treatment planning for colorectal polyps using a deep-learning model

    We aimed to develop a computer-aided diagnostic system (CAD) for predicting colorectal polyp histology using deep-learning technology and to validate its performance. Near-focus narrow-band imaging (NBI) pictu...

    Eun Mi Song, Beomhee Park, Chun-Ae Ha, Sung Wook Hwang in Scientific Reports (2020)

  10. Article

    Open Access

    Immunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance

    Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple imm...

    Jae Seung Soh, Su In Jo, Hye** Lee, Eun-ju Do, Sung Wook Hwang in Scientific Reports (2019)

  11. Article

    Open Access

    Endoscopic Transplantation of Mesenchymal Stem Cell Sheets in Experimental Colitis in Rats

    Owing to the recent progress in regenerative medicine technology, clinical trials that harnessed the regeneration and immune modulation potentiality of stem cells for treating IBD have shown promising results....

    Sehyung Pak, Sung Wook Hwang, In Kyong Shim, Sang Mun Bae in Scientific Reports (2018)

  12. Article

    Open Access

    Elevated C-reactive protein is associated with disease progression in patients with mild Crohn’s disease

    Few studies have been conducted on the progression of mild Crohn’s disease (CD). We aimed to investigate the natural course in mild CD patients with or without bowel damage, to identify predictors of bowel res...

    Min Seob Kwak, Kyung-Jo Kim, Sang Hyoung Park, Dong-Hoon Yang, Byong Duk Ye in SpringerPlus (2016)