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  1. Article

    Open Access

    Characterisation and reproducibility of the HumanMethylationEPIC v2.0 BeadChip for DNA methylation profiling

    The Illumina family of Infinium Methylation BeadChip microarrays has been widely used over the last 15 years for genome-wide DNA methylation profiling, including large-scale and population-based studies, due t...

    Timothy J. Peters, Braydon Meyer, Lauren Ryan, Joanna Achinger-Kawecka… in BMC Genomics (2024)

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  2. Article

    Open Access

    The potential of epigenetic therapy to target the 3D epigenome in endocrine-resistant breast cancer

    Three-dimensional (3D) epigenome remodeling is an important mechanism of gene deregulation in cancer. However, its potential as a target to counteract therapy resistance remains largely unaddressed. Here, we s...

    Joanna Achinger-Kawecka, Clare Stirzaker… in Nature Structural & Molecular Biology (2024)

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  3. Article

    Open Access

    Evaluation of the safety and efficacy of a novel product for the removal of impacted human cerumen

    This open-label study evaluated the safety and efficacy of a novel product for the removal of impacted cerumen in adult patients.

    Douglas Fullington, Jenny Song, Antionette Gilles… in BMC Ear, Nose and Throat Disorders (2017)

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  4. No Access

    Article

    Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

    We report a new mechanism in carcinogenesis involving coordinate long-range epigenetic gene silencing. Epigenetic silencing in cancer has always been envisaged as a local event silencing discrete genes. Howeve...

    Jordi Frigola, Jenny Song, Clare Stirzaker, Rebecca A Hinshelwood… in Nature Genetics (2006)