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Article

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

Interferon-induced transmembrane proteins (IFITMs 1, 2 and 3) have emerged as important innate immune effectors that prevent diverse virus infections in vertebrates. However, the cellular mechanisms and live-c...

Jennifer S. Spence, Ruina He, Hans-Heinrich Hoffmann… in Nature Chemical Biology (2019)