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Article
Retrospective assessment of patterns of recurrence relative to radiotherapy volumes for adjuvant conformal chemoradiotherapy in gastric cancer
Since the Intergroup 0116 study was published in 2000, adjuvant postoperative chemoradiotherapy using CT-planned and 3D conformal/intensity-modulated radiotherapy has been offered routinely to fit patients wit...
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Article
Spatial genomic heterogeneity within localized, multifocal prostate cancer
Paul Boutros, Robert Bristow and colleagues report a molecular analysis of the spatial heterogeneity of clinically localized, multifocal prostate cancer. They find that multifocal tumors are highly heterogeneo...
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Article
Gastric cancer recurrence after resection and adjuvant chemoradiation
Surgery remains the primary therapy for locally advanced gastric cancer, but locoregional recurrence (LRR) has been documented in up to 68.6 % of patients with surgery alone. Peri- or post-operative adjuvant t...
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Article
Open AccessPostoperative radiotherapy improves local control and survival in patients with uterine leiomyosarcoma
To examine the role of radiotherapy (RT) in uterine leiomyosarcomas (LMS) and to determine the patient population who may benefit from RT.
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Article
Open AccessAddition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data
The upcoming release of new whole-genome genoty** technologies will shed new light on whether there is an associative effect of previously immeasurable rare variants on incidence of disease. For Genetic Anal...
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Article
Open AccessA pathway-based association analysis model using common and rare variants
How various genetic effects in combination affect susceptibility to certain disease states continues to be a major area of methodological research. Various rare variant models have been proposed, in response t...
