Skip to main content

2 Result(s)

within Jemma Betts Remove this filter

and

  1. Article

    Open Access

    A structural basis for prion strain diversity

    Recent cryogenic electron microscopy (cryo-EM) studies of infectious, ex vivo, prion fibrils from hamster 263K and mouse RML prion strains revealed a similar, parallel in-register intermolecular β-sheet (PIRIB...

    Szymon W. Manka, Adam Wenborn, Jemma Betts, Susan Joiner… in Nature Chemical Biology (2023)

    Download PDF (7077 KB) View Article

  2. Article

    Open Access

    2.7 Å cryo-EM structure of ex vivo RML prion fibrils

    Mammalian prions propagate as distinct strains and are composed of multichain assemblies of misfolded host-encoded prion protein (PrP). Here, we present a near-atomic resolution cryo-EM structure of PrP fibril...

    Szymon W. Manka, Wenjuan Zhang, Adam Wenborn, Jemma Betts… in Nature Communications (2022)

    Download PDF (3474 KB) View Article