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Article
Open AccessCharacterization of SARS-CoV-2 and host entry factors distribution in a COVID-19 autopsy series
SARS-CoV-2 is a highly contagious virus that causes the disease COVID-19. We have recently reported that androgens regulate the expression of SARS-CoV-2 host entry factors ACE2 and TMPRSS2, and androgen recept...
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Chapter
Histopathology of IPF and Related Disorders
Histopathologic classification schemes provide the underpinnings for separating idiopathic interstitial pneumonias into clinically meaningful groups. A number of multidisciplinary position papers and guideline...
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Chapter
Incidental Findings and Lesions of Limited Clinical Significance
Incidental findings of little, unknown, or limited diagnostic significance (Figs. 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9, 2.10 and 2.11) are common and may confound histologic interpretation of both large...
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Chapter
Transplant-Related Disorders
With the advance of lung allogeneic transplantation, more and more transbronchial biopsies are encountered by surgical pathologists, mainly for the purpose of the monitoring and diagnosis of allograft rejectio...
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Chapter
Pulmonary Lymphoproliferative Diseases
Mucosa-associated lymphoid tissue (MALT) in the lungs, also known as bronchus-associated lymphoid tissue (BALT), is present along the respiratory mucosa and is normally inconspicuous in the adult lung. MALT pa...
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Chapter
Normal Structures and Common Artifacts
A general knowledge of normal lung structure (Figs. 1.1, 1.2, 1.3, 1.4 and 1.5) and common artifacts (Figs. 1.6, 1.7, 1.8 and 1.9) is critical for interpreting lung biopsies. Histologically, there two major ty...
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Chapter
Pediatric Disorders
Diseases commonly encountered in pediatric lung biopsies and resections are significantly different from those encountered in adult surgical lung specimens. Certain tumor types, including solitary fibrous tumo...
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Chapter
Diseases of Cartilaginous and Noncartilaginous Airways
Diseases of cartilaginous (large) and noncartilaginous (small) airways include various nonspecific inflammatory and destructive lesions. The diagnoses of these diseases are usually made clinically and rarely r...
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Chapter
Noninfectious Diffuse Granulomatous Lung Diseases
This chapter illustrates the two main forms of noninfectious diffuse granulomatous lung disease likely to be encountered in lung biopsies: hypersensitivity pneumonia and sarcoidosis. Hypersensitivity pneumonia...
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Chapter
Pulmonary Vascular Diseases
Two major categories of pulmonary vascular diseases are discussed in this chapter: noninflammatory vascular disorders and inflammatory vascular diseases (vasculitis). Noninflammatory vascular disorders encompa...
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Chapter
Pneumoconiosis
Pneumoconiosis is a nonneoplastic reaction of the lung to inhaled inorganic particles. Most affected patients are diagnosed based on a combination of an occupational history, pulmonary function texts, and radi...
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Chapter
Benign Lung Neoplasms
Although most lung neoplasms are malignant, a small subset of true lung neoplasms are benign (Table 12.1). Benign lung neoplasms include epithelial and mesenchymal tumors, with pulmonary hamartoma being the si...
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Chapter
Malignant Nonepithelial Lung and Pleural Neoplasms
Mesenchyme-derived malignant neoplasms of the lung are rare, although virtually any type of soft-tissue sarcoma can occur in the lungs, ranging from tumors of low malignant potential to high-grade sarcomas. Am...
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Chapter
Infectious Diseases
Pulmonary infections are caused by a wide range of pathogenic microorganisms, including bacteria, viruses, fungi, and parasites. The most common lung infections in immunocompetent hosts are caused by pyogenic ...
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Chapter
Diffuse Nongranulomatous Lung Disorders
Diffuse, nonneoplastic lung diseases are a large and heterogeneous group of disorders with overlap** clinical features, usually including breathlessness and cough; diffuse radiologic abnormalities are also c...
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Chapter
Lung Carcinoma
The classification and diagnostic criteria for lung carcinoma, the deadliest cancer in humans, undergo periodic updates. The 2015 World Health Organization (WHO) classification highlights changes in several ca...
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Article
Prospective, Longitudinal Study of Plastic Bronchitis Cast Pathology and Responsiveness to Tissue Plasminogen Activator
Plastic bronchitis (PB) is a rare disease that often occurs in patients with congenital heart disease (CHD) who have undergone staged single-ventricle palliation. It is characterized by the formation of rubber...
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Chapter
Common Pathways and Patterns of Injury
Pulmonary diseases often affect the lung parenchyma in a relatively specific and predictable distribution. In addition, a striking or predominant histopathologic feature (e.g., nonnecrotizing granulomas in sar...
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Chapter
Bronchiolitis Obliterans with Organizing Pneumonia and Constrictive Bronchiolitis: Comparative Analysis of Two Distinct Entities
The term bronchiolitis obliterans has been used to refer to a broad range of clinicopathologic entities.1 Bronchiolitis obliterans has been used in the clinical literature to refer to a pathologically heterogeneo...
