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    Article

    Genome-wide comparison of human keratinocyte and squamous cell carcinoma responses to UVB irradiation: implications for skin and epithelial cancer

    To gain insight into the transformation of epidermal cells into squamous carcinoma cells (SCC), we compared the response to ultraviolet B radiation (UVB) of normal human epidermal keratinocytes (NHEK) versus t...

    Jean-Eudes Dazard, Hilah Gal, Ninette Amariglio, Gideon Rechavi, Eytan Domany… in Oncogene (2003)

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    Article

    P16INK4A is implicated in both the immediate and adaptative response of human keratinocytes to UVB irradiation

    The p16INK4A-ARF locus plays a crucial role in the control of cellular proliferation via both the Rb and P53 pathways. We previously demonstrated that this locus is altered in human skin carcinomas. In the presen...

    Marjorie Chazal, Claire Marionnet, Laurence Michel, Karine Mollier… in Oncogene (2002)

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    Article

    Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size

    p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. The role of the p5...

    Jean-Eudes Dazard, Jacques Piette, Nicole Basset-Seguin, Jean-Marie Blanchard… in Oncogene (2000)

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    Article

    MDM-2 protein is expressed in different layers of normal human skin

    MDM-2 is one of the target genes of the p53 tumor suppressor protein. Its best characterized function is found in the inhibition of p53's ability to modulate transcription. Deregulated expression of MDM-2 could t...

    Jean-Eudes Dazard, Didier Augias, Henry Neel, Valérie Mils, Vincent Marechal… in Oncogene (1997)