9 Result(s)
within
Jean-Benoit Hardouin
Statistical Theory and Methods
Theory of Medicine/Bioethics
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Article
Open AccessPosttraumatic growth inventory: challenges with its validation among French cancer patients
The Posttraumatic growth inventory (PTGI) aims to assess the positive psychological changes that individuals can perceive after a traumatic life event such as a cancer diagnosis. Several French translations of...
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Article
Open AccessEvaluating the impact of calibration of patient-reported outcomes measures on results from randomized clinical trials: a simulation study based on Rasch measurement theory
Meaningfully interpreting patient-reported outcomes (PRO) results from randomized clinical trials requires that the PRO scores obtained in the trial have the same meaning across patients and previous applicati...
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Article
Open AccessThe minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation
Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic in...
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Article
Open AccessRasch modelling to deal with changes in the questionnaires used during long-term follow-up of cohort studies: a simulation study
A specific measurement issue often occurs in cohort studies with long-term follow-up: the substitution of the classic instruments used to assess one or several factors or outcomes studied by new, more reliable...
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Article
Open AccessPower and sample size determination for the group comparison of patient-reported outcomes using the Rasch model: impact of a misspecification of the parameters
Patient-reported outcomes (PRO) are important as endpoints in clinical trials and epidemiological studies. Guidelines for the development of PRO instruments and analysis of PRO data have emphasized the need to...
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Open AccessA simple ratio-based approach for power and sample size determination for 2-group comparison using Rasch models
Despite the widespread use of patient-reported Outcomes (PRO) in clinical studies, their design remains a challenge. Justification of study size is hardly provided, especially when a Rasch model is planned for...
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Article
Open AccessSpatio-temporal Rasch analysis of quality of life outcomes in the French general population. Measurement invariance and group comparisons
This study aims at analyzing Health related quality of life (HRQoL) data on the French general population between 1995 and 2003 using an Item Response Theory (IRT) model.
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Article
Open AccessImputation by the mean score should be avoided when validating a Patient Reported Outcomes questionnaire by a Rasch model in presence of informative missing data
Nowadays, more and more clinical scales consisting in responses given by the patients to some items (Patient Reported Outcomes - PRO), are validated with models based on Item Response Theory, and more specific...
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Article
Open AccessMethodological issues regarding power of classical test theory (CTT) and item response theory (IRT)-based approaches for the comparison of patient-reported outcomes in two groups of patients - a simulation study
Patients-Reported Outcomes (PRO) are increasingly used in clinical and epidemiological research. Two main types of analytical strategies can be found for these data: classical test theory (CTT) based on the ob...
