42 Result(s)
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Jean-Benoit Hardouin
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Article
Open AccessIntravenous acetaminophen with morphine versus intravenous morphine alone for acute pain in the emergency room: protocol for a multicenter, randomized, placebo-controlled, double-blinded study (ADAMOPA)
In emergency medicine, pain is a frequent reason for consultation. However, there is a great variation in its management which is often insufficient. The use intravenous morphine alone or multimodal analgesia ...
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Open AccessPosttraumatic growth inventory: challenges with its validation among French cancer patients
The Posttraumatic growth inventory (PTGI) aims to assess the positive psychological changes that individuals can perceive after a traumatic life event such as a cancer diagnosis. Several French translations of...
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Open AccessEvaluating the impact of calibration of patient-reported outcomes measures on results from randomized clinical trials: a simulation study based on Rasch measurement theory
Meaningfully interpreting patient-reported outcomes (PRO) results from randomized clinical trials requires that the PRO scores obtained in the trial have the same meaning across patients and previous applicati...
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Open AccessHow do people who use drugs receiving Opioid Medication Therapy perceive their treatment ? A multicentre study
The resurgence of heroin use and the misuse of pharmaceutical opioids are some of the reasons for a worldwide increase in opioid dependence. Opioid Medication Therapies (OMT) have amply demonstrated their effi...
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Investigation of measurement invariance in longitudinal health-related quality of life in preemptive or previously dialyzed kidney transplant recipients
Kidney transplantation (KT) can impact patients’ evaluation of health-related quality of life (HRQoL) as they adapt to their new life with a graft and its changes. Patients may adapt to KT in a different way, ...
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Article
Evaluation of the link between the Guttman errors and response shift at the individual level
Methods for response shift (RS) detection at the individual level could be of great interest when analyzing changes in patient-reported outcome data. Guttman errors (GEs), which measure discrepancies in respon...
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Article
LeSCoD: a new clinical scale for the detection of Lewy body disease in neurocognitive disorders
Dementia with Lewy bodies remains underdiagnosed in clinical practice mainly because of the low sensitivity of existing diagnostic criteria and a strong overlap with Alzheimer’s pathology that can mask the Lew...
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Open AccessThe minimal perceived change: a formal model of the responder definition according to the patient’s meaning of change for patient-reported outcome data analysis and interpretation
Patient-Reported Outcomes (PROs) are standardized questionnaires used to measure subjective outcomes such as quality of life in healthcare. They are considered paramount to assess the results of therapeutic in...
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Open AccessSafety and efficacy of low-dose intravenous arsenic trioxide in systemic lupus erythematosus: an open-label phase IIa trial (Lupsenic)
Lupus animal model has shown that arsenic trioxide (ATO), a treatment of acute promyelocytic leukaemia, could be effective in SLE. This is the first clinical study to determine the safety and efficacy of a sho...
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Reply to letter to editor: “RespOnse Shift ALgorithm in item response theory (ROSALI) for response shift detection with missing data in longitudinal patient-reported outcome studies”
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Article
How do doctors perceive and use patient quality of life? Findings from focus group interviews with hospital doctors and general practitioners
While studies on patients’ quality of life (QoL) are numerous, to date few have addressed the issue of what QoL means for doctors and how they use patient-reported QoL. This study aimed to explore how doctors ...
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Article
Open AccessPractical issues encountered while determining Minimal Clinically Important Difference in Patient-Reported Outcomes
Using a real dataset, we highlighted several major methodological issues raised by the estimation of the Minimal Clinically Important Difference (MCID) of a Patient-Reported Outcomes instrument. We especially ...
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Article
Comparison of longitudinal quality of life outcomes in preemptive and dialyzed patients on waiting list for kidney transplantation
The waiting list period for kidney transplantation can be lengthy and associated with a deteriorated health-related quality of life (HRQoL). It might also be experienced differently depending on the experience...
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Article
Open AccessPrevalence of hypobetalipoproteinemia and related psychiatric characteristics in a psychiatric population: results from the retrospective HYPOPSY Study
Hypobetalipoproteinemia (HBL) is defined by plasma concentrations of LDL-cholesterol (LDL-C) lower than the fifth percentile for age and sex. Several psychiatric symptoms have been reported in association with...
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Article
Open AccessIs intravenously administered, subdissociative-dose KETAmine non-inferior to MORPHine for prehospital analgesia (the KETAMORPH study): study protocol for a randomized controlled trial
Acute pain is a common condition among prehospital patients and prompt management is pivotal. Opioids are the most frequently analgesics used in the prehospital setting. However, opioids are highly addictive, ...
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Article
Assessment of the Aldosteronona resolution score as a predictive resolution score of hypertension after adrenalectomy for aldosteronoma in French patients
Aldosteronoma Resolution Score (ARS) is a predictive score for cure of hypertension after adrenalectomy for hyperaldosteronism and has been validated in American patients. The aim of the study was to validate ...
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Article
Open AccessValidation of the French versions of the Hirschsprung’s disease and Anorectal malformations Quality of Life (HAQL) questionnaires for adolescents and adults
The Hirschsprung’s disease Anorectal malformation QoL questionnaire (HAQL) is a disease-specific quality of life (QoL) questionnaire for patients with Hirschsprung’s disease (HD) or anorectal malformations (AR...
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Article
Sustained quality of life improvement after intracoronary injection of autologous bone marrow cells in the setting of acute myocardial infarction: results from the BONAMI trial
Cardiac cell therapy is a promising treatment for acute myocardial infarction (AMI), leading to cardiac function improvement. However, whether it translates into quality of life (QoL) improvement is unclear. W...
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Open AccessRasch modelling to deal with changes in the questionnaires used during long-term follow-up of cohort studies: a simulation study
A specific measurement issue often occurs in cohort studies with long-term follow-up: the substitution of the classic instruments used to assess one or several factors or outcomes studied by new, more reliable...
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The Guttman errors as a tool for response shift detection at subgroup and item levels
Statistical methods for identifying response shift (RS) at the individual level could be of great practical value in interpreting change in PRO data. Guttman errors (GE) may help to identify discrepancies in r...
