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Chapter
Endoscopy
Diverticular disease is often an unexpected diagnosis in patients undergoing colonoscopy due to abdominal pain, rectal bleeding, or colorectal cancer screening. Colonoscopy plays a key role in different clinic...
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Article
Open AccessLongitudinal analysis of healthy colon establishes aspirin as a suppressor of cancer-related epigenetic aging
Colon cancer (CC) is the third most common cancer worldwide, highlighting the importance of develo** effective prevention strategies. Accumulating evidence supports that aspirin use reduces CC incidence. We ...
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Article
Open AccessAssociation of genetic variation in the NR1H4 gene, encoding the nuclear bile acid receptor FXR, with inflammatory bowel disease
Pathogenesis of inflammatory bowel diseases (IBD), ulcerative colitis (UC) and Crohn’s disease (CD), involves interaction between environmental factors and inappropriate immune responses in the intestine of ge...
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Article
Should There Be Gender Differences in the Guidelines for Colorectal Cancer Screening?
Colorectal cancer screening guidelines are identical for men and women despite reported differences in epidemiology, endoscopy performance, screening preferences, and screening uptake. High-quality research is...
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Article
Considering Gender Differences When Planning a Screening Program
In light of the huge population at risk for colorectal cancer (CRC) and limited screening resources, shifting the use of screening tests from low-risk to high-risk groups is a valid option. This study reviews ...
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Article
Open AccessStill No Meta-Analysis of Screening Colonoscopy for Colorectal Cancer?
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Article
Large intra- and inter-individual variability of genes expression levels limits potential predictive value of molecular diagnosis of dysplasia in Barrett’s esophagus
Barrett’s esophagus represents a well-defined precursor lesion of esophageal adenocarcinoma, although only a subset of patients with these lesions advances to invasive cancer. Currently, reliable markers predi...
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Article
Open AccessReliability and validity of the Gastrointestinal Symptom Rating Scale (GSRS) and Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire in dyspepsia: A six-country study
Symptoms of dyspepsia significantly disrupt patients' lives and reliable methods of assessing symptom status are important for patient management. The aim of the current study was to document the psychometric ...
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Article
Colorectal cancer screening: Selected issues
This article summarizes the most important recent articles on colonoscopy as a screening tool for colorectal cancer, presenting screening outcomes and quality issues. We also refer to the first published resul...
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Article
Molecular defense mechanisms of Barrett’s metaplasia estimated by an integrative genomics
Barrett’s esophagus is characterized by the replacement of squamous epithelium with specialized intestinal metaplastic mucosa. The exact mechanisms of initiation and development of Barrett’s metaplasia remain ...
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Article
Three clinical variants of gastroesophageal reflux disease form two distinct gene expression signatures
It has been proposed recently that gastroesophageal reflux disease (GERD) patients may be categorized into three distinct groups exhibiting non-erosive reflux disease (NERD), erosive reflux disease (ERD), and ...
