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Protocol
Combating Viral Diseases in the Era of Systems Medicine
Viruses can cause many diseases resulting in disabilities and death. Fortunately, advances in systems medicine enable the development of effective therapies for treating viral diseases, of vaccines to prevent ...
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Article
FDA-Industry Scientific Exchange on assessing quantitative systems pharmacology models in clinical drug development: a meeting report, summary of challenges/gaps, and future perspective
The pharmaceutical industry is actively applying quantitative systems pharmacology (QSP) to make internal decisions and guide drug development. To facilitate the eventual development of a common framework for ...
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Article
Translational Quantitative Systems Pharmacology in Drug Development: from Current Landscape to Good Practices
Systems pharmacology approaches have the capability of quantitatively linking the key biological molecules relevant to a drug candidate’s mechanism of action (drug-induced signaling pathways) to the clinical b...
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Protocol
A Computational Platform and Guide for Acceleration of Novel Medicines and Personalized Medicine
In the era of big data and informatics, computational integration of data across the hierarchical structures of human biology enables discovery of new druggable targets of disease and new mode of action of a d...
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Article
Strategic Applications of Gene Expression: From Drug Discovery/Development to Bedside
Gene expression is useful for identifying the molecular signature of a disease and for correlating a pharmacodynamic marker with the dose-dependent cellular responses to exposure of a drug. Gene expression off...
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Article
Strategic Biomarkers for Drug Development in Treating Rare Diseases and Diseases in Neonates and Infants
There are similar challenges in develo** a product designed to treat patients with a rare disease and drugs to treat critically ill neonates and infants. Part of the challenge in develo** such products as ...
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Article
Erratum to: Translational Biomarkers: from Preclinical to Clinical a Report of 2009 AAPS/ACCP Biomarker Workshop
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Article
Translational Biomarkers: from Preclinical to Clinical a Report of 2009 AAPS/ACCP Biomarker Workshop
There have been some successes in qualifying biomarkers and applying them to drug development and clinical treatment of various diseases. A recent success is illustrated by a collaborative effort among the US ...
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Article
Successes Achieved and Challenges Ahead in Translating Biomarkers into Clinical Applications
Biomarkers are important tools for identifying and stratifying diseases, predicting their progression and determining the effectiveness, safety, and doses of therapeutic interventions. This is important for co...
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Article
Evidence for the Existence of Insulin-Degrading Enzyme on the Brush-Border Membranes of Rat Enterocytes
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Article
Transepithelial Transport of Insulin: I. Insulin Degradation by Insulin-Degrading Enzyme in Small Intestinal Epithelium
Purpose. The purpose of this study was to determine the existence of insulin-degrading enzyme (EC 3.4.22.11) (IDE) in rat intestinal enterocytes.
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Article
pGlu-L-Dopa-Pro: A Tripeptide Prodrug Targeting the Intestinal Peptide Transporter for Absorption and Tissue Enzymes for Conversion
Purpose. The purpose of this study is to investigate the characteristics of pGlu-L-Dopa-Pro as a prodrug of L-Dopa.
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Article
Insulin-Degrading Enzyme in a Human Colon Adenocarcinoma Cell Line (Caco-2)
The activity of insulin-degrading enzyme (IDE), a thiol metalloprotease degrading insulin in many insulin target cells, was determined in human colon adenocarcinoma (Caco-2) cells. Insulin-degrading activity w...
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Article
Metabolism of Acetylneurotensin(8–13) by Proteolytic Activities of Intestinal Enterocytes
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Article
Distribution of Brush-Border Membrane Peptidases Along the Rat Intestine
The longitudinal distribution of brush-border endopeptidase-24.11, endopeptidase-2, aminopeptidase W, angiotensin-converting enzyme (ACE), dipeptidyl peptidase IV (DPP IV), carboxypeptidase P, and aminopeptida...
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Article
Structural Specificity of Mucosal-Cell Transport and Metabolism of Peptide Drugs: Implication for Oral Peptide Drug Delivery
The brush border membrane of intestinal mucosal cells contains a peptide carrier system with rather broad substrate specificity and various endo- and exopeptidase activities. Small peptide (di-/ tripeptide)-ty...
