10 Result(s)

Article

Low-risk susceptibility alleles in 40 human breast cancer cell lines

Low-risk breast cancer susceptibility alleles or SNPs confer only modest breast cancer risks ranging from just over 1.0 to1.3 fold. Yet, they are common among most populations and therefore are involved in the...

Muhammad Riaz, Fons Elstrodt, Antoinette Hollestelle, Abbas Dehghan… in BMC Cancer (2009)

Article

Standard psychological consultations and follow up for women at increased risk of hereditary breast cancer considering prophylactic mastectomy

Women at increased (genetic) risk of breast cancer have to weigh the personal pros and cons of prophylactic mastectomy (PM) as an option to reduce their cancer risk. So far, no routine referral to a psychologi...

Murly BM Tan, Eveline MA Bleiker… in Hereditary Cancer in Clinical Practice (2009)

Article

A family history of breast cancer will not predict female early onset breast cancer in a population-based setting

An increased risk of breast cancer for relatives of breast cancer patients has been demonstrated in many studies, and having a relative diagnosed with breast cancer at an early age is an indication for breast ...

Geertruida H de Bock, Catharina E Jacobi, Caroline Seynaeve… in BMC Cancer (2008)

Article

Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases

Seven SNPs in five genomic loci were recently found to confer a mildly increased risk of breast cancer.

Petra EA Huijts, Maaike PG Vreeswijk, Karin HG Kroeze-Jansema… in Breast Cancer Research (2007)

Article

Pathway analysis of gene signatures predicting metastasis of node-negative primary breast cancer

Published prognostic gene signatures in breast cancer have few genes in common. Here we provide a rationale for this observation by studying the prognostic power and the underlying biological pathways of diffe...

Jack X Yu, Anieta M Sieuwerts, Yi Zhang, John WM Martens, Marcel Smid… in BMC Cancer (2007)

Article

GnRH and LHRgene variants predict adverse outcome in premenopausal breast cancer patients

Breast cancer development and progression are dependent on estrogen activity. In premenopausal women, estrogen production is mainly regulated through the hypothalamic-pituitary-gonadal (HPG) axis.

Djura Piersma, Axel PN Themmen, Maxime P Look, Jan GM Klijn… in Breast Cancer Research (2007)

Article

Identification of women with an increased risk of develo** radiation-induced breast cancer: a case only study

Radiation exposure at a young age is one of the strongest risk factors for breast cancer. Germline mutations in genes involved in the DNA-damage repair pathway (DDRP) may render women more susceptible to radia...

Annegien Broeks, Linde M Braaf, Angelina Huseinovic, Anke Nooijen… in Breast Cancer Research (2007)

Article

Comment on Screening by MRI Mentioned in the Reviews by Narod and Møller

Mieke Kriege, Cecile TM Brekelmans, Jan GM Klijn in Hereditary Cancer in Clinical Practice (2004)