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Article
Open AccessAssociation of biochemical markers with bone marrow lesion changes on imaging—data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium
To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relation...
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Article
Open AccessBiomarkers in osteoarthritis: current status and outlook — the FNIH Biomarkers Consortium PROGRESS OA study
Currently, no disease-modifying therapies are approved for osteoarthritis (OA) use. One obstacle to trial success in this field has been our existing endpoints’ limited validity and responsiveness. To overcome...
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Article
Open AccessStructural phenotypes of knee osteoarthritis: potential clinical and research relevance
A joint contains many different tissues that can exhibit pathological changes, providing many potential targets for treatment. Researchers are increasingly suggesting that osteoarthritis (OA) comprises several...
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Open AccessA longitudinal rat model for assessing postoperative recovery and bone healing following tibial osteotomy and plate fixation
Rodent models are commonly employed to validate preclinical disease models through the evaluation of postoperative behavior and allodynia. Our study investigates the dynamic interplay between pain and function...
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Article
Genicular Artery Embolization as a Treatment for Osteoarthritis Related Knee Pain: A Systematic Review and Meta-analysis
Genicular artery embolization (GAE) is a minimally invasive therapy for symptomatic osteoarthritis (OA) in patients with knee pain refractory to conservative management. The purpose of this study was to evalua...
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Open AccessCorrection to: The likelihood of total knee arthroplasty following arthroscopic surgery for osteoarthritis: a systematic review
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Article
Increased postoperative dexamethasone and gabapentin reduces opioid consumption after total knee arthroplasty
Dexamethasone and gabapentin are used in multimodal pain management protocols to reduce postoperative pain after total knee arthroplasty. For both analgesic adjuvants, the optimal dose regimen to reduce opioid...
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Article
Do modern total knee replacements improve tibial coverage?
The purpose of the present study is to compare newer designs of various symmetric and asymmetric tibial components and measure tibial bone coverage using the rotational safe zone defined by two commonly utiliz...
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Article
Open AccessImplementation of a workplace intervention using financial rewards to promote adherence to physical activity guidelines: a feasibility study
We designed and implemented the Brigham and Women’s Wellness Initiative (B-Well), a single-arm study to examine the feasibility of a workplace program that used individual and team-based financial incentives t...
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Open AccessThe likelihood of total knee arthroplasty following arthroscopic surgery for osteoarthritis: a systematic review
Arthroscopic surgery is a common treatment for knee osteoarthritis (OA), particularly for symptomatic meniscal tear. Many patients with knee OA who have arthroscopies go on to have total knee arthroplasty (TKA...
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Article
Open AccessSemi-quantitative MRI biomarkers of knee osteoarthritis progression in the FNIH biomarkers consortium cohort − Methodologic aspects and definition of change
To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the ex...
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Article
Open AccessAssociation between activity limitations and pain in patients scheduled for total knee arthroplasty
Historically, persons scheduled for total knee arthroplasty (TKA) have reported severe pain with low demand activities such as walking, but recent data suggests that TKA recipients may have less preoperative p...
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Article
Open AccessDevelopment and feasibility of a personalized, interactive risk calculator for knee osteoarthritis
The incidence of knee osteoarthritis (OA) is rising. While several risk factors have been associated with the development of knee OA, this information is not readily accessible to those at risk for osteoarthri...
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Article
Open AccessEffect of smoking and soft tissue release on risk of revision after total knee arthroplasty: a case- control study
Increasing utilization of primary total knee arthroplasty (TKA) is projected to expand demand for revision TKA. Revision TKAs are procedurally complex and incur high costs on our financially constrained health...
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Article
Open AccessParticipation in physical activity in patients 1–4 years post total joint replacement in the Dominican Republic
To address both the growing burden of joint disease and the gaps in medical access in develo** nations, medical relief organizations have begun to launch programs to perform total joint replacement (TJR) on ...
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Article
Open AccessDevelopment and validation of a Spanish translation of the Yale activity questionnaire
Valid measures of physical activity are critical research tools. The objective of this study was to develop a Spanish translation of the Yale Physical Activity Survey, and to provide preliminary evidence of it...
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Article
Open AccessThe AViKA (Adding Value in Knee Arthroplasty) postoperative care navigation trial: rationale and design features
Utilization of total knee arthroplasty is increasing rapidly. A substantial number of total knee arthroplasty recipients have persistent pain after surgery. Our objective was to design a randomized controlled ...
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Article
Open AccessReliability of medical record abstraction by non-physicians for orthopedic research
Medical record review (MRR) is one of the most commonly used research methods in clinical studies because it provides rich clinical detail. However, because MRR involves subjective interpretation of informatio...
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Article
Open AccessObesity & hypertension are determinants of poor hemodynamic control during total joint arthroplasty: a retrospective review
Proper blood pressure control during surgical procedures such as total joint arthroplasty (TJA) is considered critical to good outcome. There is poor understanding of the pre-operative risk factors for poor in...
