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Article
Deep learning-based prediction of the T cell receptor–antigen binding specificity
Neoantigens play a key role in the recognition of tumour cells by T cells; however, only a small proportion of neoantigens truly elicit T-cell responses, and few clues exist as to which neoantigens are recogni...
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Article
Open AccessClearance of a persistent picornavirus infection is associated with enhanced pro-apoptotic and cellular immune responses
Long-term persistent viral infections cause substantial morbidity and associated economic losses in human and veterinary contexts. Yet, the mechanisms associated with establishment of persistent infections are...
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Article
Open AccessExpression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival
Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cer...
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Article
Carboxypeptidase E, an essential element of the regulated secretory pathway, is expressed and partially co-localized with chromogranin A in chicken thymus
Although the functions of hormones and neuropeptides in the thymus have been extensively studied, we still do not know whether these intra-thymic humoral elements are released in a stimulated manner via the re...
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Article
Open AccessCharacterization of a newly developed chicken 44K Agilent microarray
The development of microarray technology has greatly enhanced our ability to evaluate gene expression. In theory, the expression of all genes in a given organism can be monitored simultaneously. Sequencing of ...
