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Article
Open AccessDelta oscillations phase limit neural activity during sevoflurane anesthesia
Understanding anesthetic mechanisms with the goal of producing anesthetic states with limited systemic side effects is a major objective of neuroscience research in anesthesiology. Coherent frontal alpha oscil...
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Article
A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
Fatty acid transport from blood vessels to skeletal muscle, across endothelial cells, is regulated by the branched chain amino acid metabolite 3-hydroxy-isobutyrate. This finding provides a mechanistic explana...
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Article
Analysis of suspicious powders following the post 9/11 anthrax scare
Following the 9/11 terrorist attacks, SET Environmental, Inc., a Chicago-based environmental and hazardousmaterials management company received a large number of suspicious powders for analysis.
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Article
Insulin-regulated hepatic gluconeogenesis through FOXO1–PGC-1α interaction
Hepatic gluconeogenesis is absolutely required for survival during prolonged fasting or starvation, but is inappropriately activated in diabetes mellitus. Glucocorticoids and glucagon have strong gluconeogenic...
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Article
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
Blood glucose levels are maintained by the balance between glucose uptake by peripheral tissues and glucose secretion by the liver. Gluconeogenesis is strongly stimulated during fasting and is aberrantly activ...
