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Article
Open AccessTargeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint
Determining divergent metabolic requirements of T cells, and the viruses and tumours they fail to combat, could provide new therapeutic checkpoints. Inhibition of acyl-CoA:cholesterol acyltransferase (ACAT) ha...
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Article
Open AccessCircadian control of hepatitis B virus replication
Chronic hepatitis B virus (HBV) infection is a major cause of liver disease and cancer worldwide for which there are no curative therapies. The major challenge in curing infection is eradicating or silencing t...
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Article
Open AccessAuthor Correction: Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessHypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models
Hepatitis B virus (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalian oxygen sensing pathway an...
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Article
Open AccessAccurate targeted long-read DNA methylation and hydroxymethylation sequencing with TAPS
We present long-read Tet-assisted pyridine borane sequencing (lrTAPS) for targeted base-resolution sequencing of DNA methylation and hydroxymethylation in regions up to 10 kb from nanogram-level input. Compati...
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The Importance and Challenge of Oral Health in LMICs: Perspectives from Dental Medicine, Dental Librarianship, and Dental Administration
Everyone will be impacted by oral disease at some point in life. Dental caries (tooth decay) is the most widespread chronic disease worldwide, impacting nearly 100% of adults and 60–90% of school children. In ...
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Chapter
Handbook of Nanomaterials Properties: Siliceous Nanobiomaterials
In the scope of silica materials across the breadth of research and technology, perhaps one of the most active and exciting research areas is that of siliceous nanobiomaterials – materials forged at the interf...
