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Article
Open AccessTranscriptional profiles in Strongyloides stercoralis males reveal deviations from the Caenorhabditis sex determination model
The human and canine parasitic nematode Strongyloides stercoralis utilizes an XX/XO sex determination system, with parasitic females reproducing by mitotic parthenogenesis and free-living males and females reprod...
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Article
Open AccessA novel assay to isolate and quantify third-stage Dirofilaria immitis and Brugia malayi larvae emerging from individual Aedes aegypti
Mosquitoes transmit filarial nematodes to both human and animal hosts, with worldwide health and economic consequences. Transmission to a vertebrate host requires that ingested microfilariae develop into infec...
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Article
Open AccessAdvances in the Molecular and Cellular Biology of Strongyloides spp.
This paper constitutes an update of recent studies on the general biology, molecular genetics, and cellular biology of Strongyloides spp. and related parasitic nematodes.
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Article
Open AccessLiposome-based transfection enhances RNAi and CRISPR-mediated mutagenesis in non-model nematode systems
Nematodes belong to one of the most diverse animal phyla. However, functional genomic studies in nematodes, other than in a few species, have often been limited in their reliability and success. Here we report...
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Article
Open AccessStructural and developmental expression of Ss-riok-2, an RIO protein kinase encoding gene of Strongyloides stercoralis
RIO kinases are essential atypical protein kinases in diverse prokaryotic and eukaryotic organisms, playing significant roles in yeast and humans. However, little is known about their functions in parasitic ne...
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Article
Open AccessSignaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival
Signaling or communication between host and parasite may occur over relatively long ranges to enable host finding and acquisition by infective parasitic nematode larvae. Innate behaviors in infective larvae tr...
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Article
Open AccessThe genomic basis of parasitism in the Strongyloides clade of nematodes
Taisei Kikuchi, Mark Viney, Matthew Berriman and colleagues report the genome sequences of six species of nematodes from the Strongyloides clade of nematodes, including human and animal pathogens, facultative par...
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Article
Open AccessReconstruction of the insulin-like signalling pathway of Haemonchus contortus
In the present study, we reconstructed the insulin/insulin-like growth factor 1 signalling (IIS) pathway for Haemonchus contortus, which is one of the most important eukaryotic pathogens of livestock worldwide an...
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Article
Open AccessMolecular characterization of the Haemonchus contortus phosphoinositide-dependent protein kinase-1 gene (Hc-pdk-1)
Phosphoinositide-dependent protein kinase-1 (PDK-1), which functions downstream of phosphoinositide 3-kinase (AGE-1) and activates protein kinases of the AGC family, plays critical roles in regulating biology ...
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Article
Open AccessExploring features and function of Ss-riok-3, an enigmatic kinase gene from Strongyloides stercoralis
Right open reading frame protein kinase 3 (RIOK-3) belongs to the atypical kinase family. Unlike the other two members, RIOK-1 and RIOK-2, which are conserved from Archaea to humans, RIOK-3 occurs only in mult...
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Article
Strongyloides stercoralis and Relatives: Recent Advances in General and Molecular Biology
Human strongyloidiasis is a threat to global health, presenting significant challenges in diagnosis and clinical management. The imperative to incorporate strongyloidiasis more fully into control programs for ...
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Article
Open AccessExploring the role of two interacting phosphoinositide 3-kinases of Haemonchus contortus
Phosphoinositide 3-kinases (PI3Ks) are relatively conserved and important intracellular lipid kinases involved in signalling and other biological pathways. In the free-living nematode Caenorhabditis elegans, the ...
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Chapter
Filariasis
Parasitic round worms (nematodes) in the superfamily Filarioidea, family Onchocercidae, are the only metazoon disease agents of vertebrates that undergo true biological transmission by arthropod vectors. These...
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Chapter
Filariasis
Parasitic round worms (nematodes) in the superfamily Filarioidea, family Onchocercidae, are the only metazoon disease agents of vertebrates that undergo true biological transmission by arthropod vectors. These...
